Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 12/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987659 | 0.69 | HTT (0.48) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL9484454 | 0.69 | LMNA (0.45) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL20363767 | 0.68 | CA12 (0.46) | SMN1; SMN2ALDH1A1LMNAKDM4EPKM | |
| SCHEMBL10120804 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL604896 | 0.67 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL8381807 | 0.67 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL604897 | 0.67 | CHRNB2 (0.54) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL965401 | 0.67 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL16658578 | 0.66 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL6538861 | 0.66 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |