Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743145 | 0.86 | TLR9 (0.46) | TLR9TLR8TLR7HRH3ERN1 | |
| SCHEMBL3242110 | 0.79 | ALDH1A1 (0.55) | DGAT1 | |
| SCHEMBL1742828 | 0.79 | ACVR1 (0.43) | DGAT1HRH3ERN1GPR119ACVR1 | |
| SCHEMBL1743197 | 0.77 | HRH3 (0.46) | DGAT1HRH3GPR119ACVR1 | |
| SCHEMBL1743100 | 0.76 | RET (0.43) | GPR119 | |
| SCHEMBL9987567 | 0.74 | DRD3 (0.45) | GPR119 | |
| SCHEMBL27921240 | 0.72 | TLR9 (0.44) | TLR9TLR8TLR7HRH3ACVR1 | |
| SCHEMBL10380301 | 0.70 | DGAT1 (0.49) | DGAT1HRH3ERN1 | |
| SCHEMBL22579216 | 0.70 | RET (0.53) | GPR119 | |
| SCHEMBL1743020 | 0.69 | HDAC4 (0.40) | TLR9TLR8TLR7HRH3ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-B1 | Histamine H3 receptor antagonists | HIGH POINT PHARMACEUTICALS LLC (US) | 2011-12-07 | — | — | EP | disclosed |