Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.45 |
| ▸ | DRD2 | P14416 | 11/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743100 | 0.88 | RET (0.43) | DRD3HTR2ADRD4HTR1ASLC6A4 | |
| SCHEMBL3242110 | 0.79 | ALDH1A1 (0.55) | — | |
| SCHEMBL1742828 | 0.79 | ACVR1 (0.43) | GPR119 | |
| SCHEMBL1743197 | 0.77 | HRH3 (0.46) | GPR119 | |
| SCHEMBL30230464 | 0.74 | KCNJ1 (0.34) | DRD3DRD2HTR2AGPR119HTR7 | |
| SCHEMBL9987565 | 0.74 | TLR9 (0.38) | GPR119 | |
| SCHEMBL1743145 | 0.74 | TLR9 (0.46) | GPR119 | |
| SCHEMBL1744111 | 0.73 | HTR7 (0.46) | GPR119HTR7 | |
| SCHEMBL10380301 | 0.73 | DGAT1 (0.49) | — | |
| SCHEMBL844318 | 0.71 | KDM4E (0.56) | DRD3DRD2HTR2ADRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-B1 | Histamine H3 receptor antagonists | HIGH POINT PHARMACEUTICALS LLC (US) | 2011-12-07 | — | — | EP | disclosed |