Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987774 | 0.86 | EGFR (0.35) | LRRK2EGFR | |
| SCHEMBL9987804 | 0.81 | CDK9 (0.35) | EGFR | |
| SCHEMBL9987599 | 0.66 | PIK3CA (0.33) | LRRK2VCP | |
| SCHEMBL2991422 | 0.64 | CDK9 (0.39) | — | |
| SCHEMBL1748831 | 0.62 | IGF1R (0.46) | EGFR | |
| SCHEMBL1748861 | 0.54 | IGF1R (0.67) | LRRK2 | |
| SCHEMBL2984674 | 0.54 | EGFR (0.39) | EGFR | |
| SCHEMBL18952058 | 0.52 | CCNB2 (0.54) | — | |
| SCHEMBL20004718 | 0.52 | SNCA (0.60) | — | |
| SCHEMBL26912470 | 0.52 | PRKDC (0.47) | TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-B1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-12-21 | — | — | EP | claimed |