Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987778 | 0.86 | TBK1 (0.36) | PIK3CAMTORLRRK2TBK1CDK9 | |
| SCHEMBL2991422 | 0.83 | CDK9 (0.39) | PIK3CAIGF1RCDK9CDK1CDK2 | |
| SCHEMBL9987808 | 0.80 | TBK1 (0.39) | IGF1RTBK1CDK9CDK1CDK2 | |
| SCHEMBL1748831 | 0.71 | IGF1R (0.46) | IGF1RCDK9CDK1CDK2CASP3 | |
| SCHEMBL2988514 | 0.69 | CDK9 (0.41) | TBK1CDK9CDK1CDK2CASP3 | |
| SCHEMBL2985765 | 0.68 | IGF1R (0.52) | IGF1RCDK9CDK1CDK2CASP3 | |
| SCHEMBL2997352 | 0.68 | CDK9 (0.40) | CDK9CDK1CDK2CASP3CASP7 | |
| SCHEMBL1748861 | 0.66 | IGF1R (0.67) | IGF1RLRRK2TBK1CDK9JAK2 | |
| SCHEMBL9987597 | 0.66 | LRRK2 (0.35) | LRRK2VCP | |
| SCHEMBL1748716 | 0.64 | IGF1R (0.46) | IGF1RLRRK2TBK1CDK9VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-B1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-12-21 | — | — | EP | claimed |