Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.35 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 10/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.33 |
| ▸ | CHUK | O15111 | 7/20 | 0.33 |
| ▸ | INSR | P06213 | 4/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987774 | 0.86 | EGFR (0.35) | CDK9CDK2CDK1CASP3CASP7 | |
| SCHEMBL9987597 | 0.81 | LRRK2 (0.35) | EGFR | |
| SCHEMBL2990264 | 0.70 | EGFR (0.38) | CDK9CDC7PIM1CDK1CAMKK2 | |
| SCHEMBL9987808 | 0.67 | TBK1 (0.39) | CDK9CDC7PIM1CDK2CDK1 | |
| SCHEMBL2987587 | 0.65 | CDK9 (0.45) | CDK9CDK2CDK1CASP3CASP7 | |
| SCHEMBL5538584 | 0.64 | CDK9 (0.40) | CDK9CDC7PIM1CDK1CAMKK2 | |
| SCHEMBL1779702 | 0.63 | MAP3K14 (0.52) | CDK9CCNT1GSK3BCLK4 | |
| SCHEMBL31240681 | 0.63 | CDK9 (0.50) | CDK9CDC7PIM1CDK2CCNT1 | |
| SCHEMBL2996608 | 0.62 | GRIN2B (0.43) | CDK9CDK2CDK1CASP3CASP7 | |
| SCHEMBL1748609 | 0.62 | CDK9 (0.47) | CDK9CDK2CDK1CASP3CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-B1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-12-21 | — | — | EP | claimed |