Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26971407 | 0.83 | L3MBTL1 (0.54) | PIN1L3MBTL1MCL1BAK1HPGD | |
| SCHEMBL9987222 | 0.83 | CNR1 (0.44) | PIN1RXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL31514805 | 0.81 | PIN1 (0.60) | PIN1L3MBTL1MCL1BAK1HPGD | |
| SCHEMBL12423709 | 0.81 | PIN1 (0.59) | PIN1L3MBTL1HPGDKDM4EMAPK1 | |
| SCHEMBL30683113 | 0.81 | PIN1 (0.59) | PIN1L3MBTL1HPGDKDM4EMAPK1 | |
| SCHEMBL18049874 | 0.81 | NUDT1 (0.55) | PIN1L3MBTL1LMNATSHRATP4A | |
| SCHEMBL30756269 | 0.81 | PIN1 (0.59) | PIN1L3MBTL1HPGDMAPK1MAPT | |
| SCHEMBL10201397 | 0.81 | PIN1 (0.59) | PIN1L3MBTL1HPGDKDM4EMAPK1 | |
| SCHEMBL2489239 | 0.80 | PIN1 (0.56) | PIN1L3MBTL1MCL1BAK1HPGD | |
| SCHEMBL2489391 | 0.78 | PIN1 (0.57) | PIN1L3MBTL1HPGDMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250313554-A1 | PTPN2 INHIBITORS | MONDEGO BIO, LDA. (PT) | 2025-10-09 | — | — | US | disclosed |
| EP-4522594-A1 | PTPN2 INHIBITORS | Ness Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| CN-119522216-A | PTPN2 inhibitors | 尼斯治疗公司 | 2025-02-25 | — | — | CN | disclosed |
| WO-2023220572-A1 | PTPN2 INHIBITORS | NESS THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250313554-A1 | PTPN2 INHIBITORS | PTPN2, PTPN1, PTPRJ | PIN1 111/4885L3MBTL1 3495/4885MCL1 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.