Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 7/20 | 0.38 |
| ▸ | ANPEP | P15144 | 4/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PEPD | P12955 | 2/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17966453 | 0.85 | MMP2 (0.49) | MMP2ANPEPPOLBALDH1A1PEPD | |
| SCHEMBL17966415 | 0.81 | PEPD (0.37) | MMP2ANPEPPOLBALDH1A1PEPD | |
| SCHEMBL4412584 | 0.77 | FKBP1A (0.47) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17966451 | 0.76 | KMT2A (0.52) | TSHRMMP2ANPEPPOLBALDH1A1 | |
| SCHEMBL8805005 | 0.75 | ALDH1A1 (0.45) | NPSR1ALDH1A1 | |
| SCHEMBL7870376 | 0.74 | NR1H2 (0.43) | NPSR1HSD17B10POLBALDH1A1FKBP1A | |
| SCHEMBL1068359 | 0.71 | TSHR (0.40) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9988131 | 0.68 | MMP2 (0.38) | MMP2ANPEPALDH1A1KMT2A | |
| SCHEMBL9988094 | 0.68 | TSHR (0.37) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9988132 | 0.68 | MMP2 (0.38) | MMP2ANPEPALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |