Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.39 |
| ▸ | CDK9 | P50750 | 7/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987778 | 0.86 | TBK1 (0.36) | TBK1CDK9CDK1CDK2CASP3 | |
| SCHEMBL2987587 | 0.84 | CDK9 (0.45) | TBK1CDK9CDK1CDK2CASP3 | |
| SCHEMBL9987599 | 0.80 | PIK3CA (0.33) | TBK1CDK9CDK1CDK2CASP3 | |
| SCHEMBL2996608 | 0.80 | GRIN2B (0.43) | CDK9CDK1CDK2CASP3CASP7 | |
| SCHEMBL2984402 | 0.80 | IGF1R (0.51) | TBK1CDK9CDK1CCNT1CDC7 | |
| SCHEMBL2985824 | 0.78 | IGF1R (0.38) | TBK1CDK9CDK1CDK2CASP3 | |
| SCHEMBL5541427 | 0.76 | IGF1R (0.41) | CDK9CDK1CDK2CASP3CASP7 | |
| SCHEMBL2990078 | 0.75 | CDK9 (0.38) | CDK9CCNT1CDC7PIM1IGF1R | |
| SCHEMBL2989437 | 0.75 | CCNT1 (0.42) | CDK9CCNT1IGF1RCHUKMAPK8 | |
| SCHEMBL27714423 | 0.75 | IGF1R (0.38) | CDK9CCNT1CDC7PIM1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799691-B1 | NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-12-21 | — | — | EP | claimed |