Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987968 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL9986551 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2AMAPTMAPK1STAT3 | |
| SCHEMBL28677033 | 0.74 | CCR2 (0.46) | ALDH1A1KMT2AMAPTLMNATSHR | |
| SCHEMBL9987042 | 0.70 | TSHR (0.40) | ALDH1A1KMT2AMAPTLMNATSHR | |
| SCHEMBL26854045 | 0.69 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTLMNATSHR | |
| SCHEMBL440604 | 0.69 | NR4A2 (0.66) | ALDH1A1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL9986322 | 0.67 | ALDH1A1 (0.40) | ALDH1A1KMT2ALMNAMAPK1STAT3 | |
| SCHEMBL11926706 | 0.66 | MYC (0.66) | ALDH1A1KMT2AMAPTLMNATSHR | |
| SCHEMBL9986429 | 0.66 | TRPM8 (0.36) | ALDH1A1KMT2AMAPK1STAT3TDP1 | |
| SCHEMBL4518839 | 0.66 | SMN1; SMN2 (0.47) | ALDH1A1KMT2AMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163195-A1 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-12-29 | — | — | WO | disclosed |