Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9988284 | 0.97 | ALDH1A1 (0.42) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL11737793 | 0.75 | MAPT (0.50) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL22548427 | 0.74 | MAPT (0.49) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL27721305 | 0.74 | MAPT (0.49) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL780293 | 0.74 | MAPT (0.49) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL27875064 | 0.71 | ALDH1A1 (0.40) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL22548166 | 0.70 | ALDH1A1 (0.45) | MAPTHTR2AALDH1A1MMP2MMP9 | |
| SCHEMBL777971 | 0.70 | MAPT (0.56) | MAPTHTR2AALDH1A1KMT2AKDM4E | |
| SCHEMBL776895 | 0.69 | MAPT (0.55) | MAPTHTR2AALDH1A1KMT2AKDM4E | |
| SCHEMBL16790918 | 0.67 | PSIP1 (0.45) | MAPTHTR2AALDH1A1KCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582374-A2 | METHODS FOR TREATING NEUROLOGICAL CONDITIONS | Afraxis, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| EP-2580216-A2 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | Afraxis, Inc. (US) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011159945-A2 | METHODS FOR TREATING NEUROLOGICAL CONDITIONS | AFRAXIS, INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011156780-A2 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |