Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9989917 | 0.88 | SLC40A1 (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2ASLC40A1 | |
| SCHEMBL2194305 | 0.87 | SLC40A1 (0.43) | SMN1; SMN2MEN1KMT2ASLC40A1BRAF | |
| SCHEMBL2193388 | 0.87 | SLC40A1 (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2AEGFR | |
| SCHEMBL9989950 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2AEGFR | |
| SCHEMBL1640536 | 0.81 | KCNQ3 (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1127143 | 0.80 | SLC40A1 (0.46) | SLC40A1BRAFHDAC3HDAC1HDAC7 | |
| SCHEMBL3422489 | 0.78 | NPC1 (0.42) | ALDH1A1SMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL1127074 | 0.78 | PKM (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AHSD11B1 | |
| SCHEMBL9989300 | 0.78 | SLC40A1 (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2AHSD11B1 | |
| SCHEMBL1127079 | 0.78 | PKM (0.41) | ALDH1A1SMN1; SMN2MEN1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319392-A1 | Thiazole Sulfonamide And Oxazole Sulfonamide Kinase Inhibitors | GLAXOSMITHKLINE LLC | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319392-A1 | Thiazole Sulfonamide And Oxazole Sulfonamide Kinase Inhibitors | STK24, MAP3K5, MAP3K2 | ALDH1A1 2613/4885SMN1; SMN2 2927/4885MEN1 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.