Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997805 | 0.94 | ABCG2 (0.45) | ABCG2ABCB1ERAP1KIF11KDM4E | |
| SCHEMBL997797 | 0.92 | ABCG2 (0.44) | ABCG2ABCB1ERAP1KDM4ESTAT3 | |
| SCHEMBL997625 | 0.89 | MAPT (0.43) | ABCG2ABCB1KIF11KDM4EALDH1A1 | |
| SCHEMBL998777 | 0.87 | ABCG2 (0.57) | ABCG2ABCB1KIF11KDM4EALDH1A1 | |
| SCHEMBL2033551 | 0.86 | KIF11 (0.47) | ABCG2ABCB1KIF11KDM4ESTAT3 | |
| SCHEMBL998052 | 0.86 | ABCG2 (0.56) | ABCG2ABCB1KIF11ALDH1A1 | |
| SCHEMBL999048 | 0.86 | PAX8 (0.45) | ABCG2ABCB1RAB9A | |
| SCHEMBL998600 | 0.85 | ABCG2 (0.53) | ABCG2ABCB1KIF11 | |
| SCHEMBL999004 | 0.85 | ABCG2 (0.45) | ABCG2ABCB1ERAP1KDM4ESTAT3 | |
| SCHEMBL2032088 | 0.85 | KIF11 (0.47) | ABCG2ABCB1KIF11KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872133-B2 | Tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20060154944-A1 | Novel tricyclic heterocycle compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-13 | — | — | US | disclosed |
| EP-1637521-A1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154944-A1 | Novel tricyclic heterocycle compound | CYP11B1, CYP11B2, HCCS | ABCG2 309/4885ABCB1 307/4885TSHR 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.