Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PON1 | P27169 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295578 | 0.98 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Sulfuric Acid SCHEMBL4443958 | 0.93 | FDPS (0.42) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Sulfuric Acid SCHEMBL2325415 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Acetone SCHEMBL15135138 | 0.91 | FDPS (0.41) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Sulfuric Acid SCHEMBL1828230 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| SCHEMBL411942 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Sulfuric Acid SCHEMBL479201 | 0.89 | FDPS (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| SCHEMBL29719229 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Methanesulfonamide SCHEMBL28366923 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTNPSR1MEN1APAF1 | |
| Hydrochloric Acid SCHEMBL194564 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084402-B2 | Method of using ionic liquids to inhibit or prevent the swelling of clay | BAKER HUGES INCORPORATED (US) | 2011-12-27 | — | — | US | claimed |