Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL9995098 | 0.95 | MAPT (0.42) | TSHRFOLH1LMNAL3MBTL1SLC1A3 | |
| Succinic Acid SCHEMBL9995351 | 0.87 | ALDH1A1 (0.44) | TSHRFOLH1L3MBTL1FFAR1FFAR4 | |
| Succinic Acid SCHEMBL9995353 | 0.86 | SLC1A3 (0.41) | FOLH1LMNASLC1A3SLC1A2SLC1A1 | |
| Adipic Acid SCHEMBL9995331 | 0.83 | ALDH1A1 (0.43) | TSHRL3MBTL1MEN1KMT2AALDH1A1 | |
| Adipic Acid SCHEMBL9995086 | 0.81 | MAPT (0.44) | FOLH1LMNASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8644381 | 0.80 | TSHR (0.50) | TSHRSLC1A1KMT2A | |
| SCHEMBL27423007 | 0.80 | TSHR (0.50) | TSHRSLC1A1KMT2A | |
| SCHEMBL2181569 | 0.78 | FOLH1 (0.49) | TSHRFOLH1SLC1A1KMT2AFFAR1 | |
| SCHEMBL2295446 | 0.77 | FOLH1 (0.51) | FOLH1SLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL5471268 | 0.77 | TSHR (0.54) | TSHRL3MBTL1SLC1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | claimed |