Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 3/20 | 0.39 |
| ▸ | TLR2 | O60603 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL9995331 | 0.96 | ALDH1A1 (0.43) | ALDH1A1CYP3A4TSHRMAPK1TDP1 | |
| Succinic Acid SCHEMBL9995221 | 0.87 | TSHR (0.41) | ALDH1A1TSHRL3MBTL1FFAR1FFAR4 | |
| Adipic Acid SCHEMBL9995098 | 0.85 | MAPT (0.42) | ALDH1A1TSHRMAPK1L3MBTL1FFAR1 | |
| Succinic Acid SCHEMBL9995353 | 0.84 | SLC1A3 (0.41) | ALDH1A1FFAR1FFAR4FOLH1 | |
| SCHEMBL22268995 | 0.83 | TLR2 (0.42) | TDP1L3MBTL1CETPTLR2 | |
| Adipic Acid SCHEMBL9995086 | 0.82 | MAPT (0.44) | ALDH1A1MAPK1FFAR1FFAR4FOLH1 | |
| SCHEMBL2949128 | 0.80 | TDP1 (0.46) | ALDH1A1CYP3A4TSHRTDP1TLR2 | |
| SCHEMBL2948589 | 0.80 | TDP1 (0.46) | ALDH1A1CYP3A4TSHRTDP1TLR2 | |
| Succinic Acid SCHEMBL2045444 | 0.78 | ALDH1A1 (0.52) | ALDH1A1CYP3A4TSHRMAPK1TDP1 | |
| SCHEMBL27130612 | 0.78 | MAPT (0.40) | TSHRTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | claimed |