Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.39 |
| ▸ | CETP | P11597 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL9995351 | 0.96 | ALDH1A1 (0.44) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| Adipic Acid SCHEMBL9995098 | 0.89 | MAPT (0.42) | ALDH1A1MAPK1TSHRL3MBTL1MAPT | |
| Adipic Acid SCHEMBL9995086 | 0.86 | MAPT (0.44) | ALDH1A1MAPK1MAPTRXFP1TBXAS1 | |
| Succinic Acid SCHEMBL9995221 | 0.83 | TSHR (0.41) | ALDH1A1TSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL22268995 | 0.82 | TLR2 (0.42) | TDP1L3MBTL1CETP | |
| Succinic Acid SCHEMBL9995353 | 0.80 | SLC1A3 (0.41) | ALDH1A1MAPTHTTMEN1KMT2A | |
| Adipic Acid SCHEMBL1409802 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL2948589 | 0.79 | TDP1 (0.46) | ALDH1A1CYP3A4TSHRTDP1PLA2G4B | |
| SCHEMBL2949128 | 0.79 | TDP1 (0.46) | ALDH1A1CYP3A4TSHRTDP1PLA2G4B | |
| SCHEMBL17377702 | 0.78 | RECQL (0.44) | ALDH1A1TSHRTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202267-B1 | Plasticizer for biodegradable aliphatic polyester resins, and biodegradable resin composition | DAIHACHI CHEM IND (JP) | 2011-12-07 | — | — | EP | claimed |