Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | DRD2 | P14416 | 2/20 | 0.76 |
| ▸ | DRD4 | P21917 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | GFER | P55789 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | BCL3 | P20749 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | POLR1A | O95602 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15825898 | 0.91 | ALDH1A1 (0.80) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL29530276 | 0.88 | LMNA (0.73) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL29373213 | 0.85 | MEN1 (0.61) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL21439851 | 0.84 | POLB (0.60) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL17554027 | 0.83 | ALDH1A1 (0.69) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL30560630 | 0.83 | ALDH1A1 (0.69) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL1185868 | 0.82 | HTR4 (0.67) | ALDH1A1DRD2DRD4POLBGFER | |
| SCHEMBL24333908 | 0.82 | NPSR1 (0.56) | ALDH1A1DRD2DRD4POLB | |
| SCHEMBL13164061 | 0.82 | NPSR1 (0.59) | ALDH1A1POLBSMN1; SMN2POLR1A | |
| SCHEMBL16430547 | 0.81 | BCL3 (0.74) | ALDH1A1DRD2DRD4POLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585470-A2 | NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHD3ITION OF TYROSINE KINASE ACTIVITY | Hanmi Science Co., Ltd. (KR) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011162515-A2 | NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHD3ITION OF TYROSINE KINASE ACTIVITY | HANMI HOLDINGS CO. , LTD. (KR) | 2011-12-29 | — | — | WO | disclosed |