Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 1.00 |
| ▸ | PIM1 | P11309 | 1/20 | 1.00 |
| ▸ | PIM3 | Q86V86 | 1/20 | 1.00 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4929327 | 0.78 | PIM1 (0.64) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL981095 | 0.77 | MCL1 (1.00) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL26933655 | 0.71 | PIM1 (0.55) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL10719531 | 0.71 | CYP3A4 (0.59) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL30435464 | 0.71 | DYRK1A (1.00) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL29019847 | 0.71 | DYRK1A (1.00) | DYRK1APIM1PIM3PIM2MCL1 | |
| 4-Methylesculetin SCHEMBL409482 | 0.70 | MCL1 (1.00) | DYRK1AMCL1KDM4EALDH1A1HSD17B10 | |
| 4-Methylesculetin SCHEMBL29361762 | 0.70 | MCL1 (1.00) | DYRK1AMCL1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL26933730 | 0.70 | ESR1 (0.63) | DYRK1APIM1PIM3PIM2MCL1 | |
| SCHEMBL24865598 | 0.69 | ALDH1A1 (0.82) | DYRK1APIM1PIM3PIM2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110305706-A1 | Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2011-12-15 | — | — | US | disclosed |