SCHEMBL981095

SCHEMBL981095

Cc1cc(=O)oc2c([N+](=O)[O-])c(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 3/20 1.00
MAOB P27338 8/20 0.63
GAA P10253 3/20 0.63
KDM4E B2RXH2 2/20 0.63
ALDH1A1 P00352 2/20 0.63
MGAM O43451 1/20 0.63
LMNA P02545 1/20 0.63
TP53 P04637 1/20 0.63
CYP3A4 P08684 1/20 0.63
MAPT P10636 1/20 0.63
SI P14410 1/20 0.63
ALOX15 P16050 1/20 0.63
MAPK1 P28482 1/20 0.63
MGAM2 Q2M2H8 1/20 0.63
PIM1 P11309 1/20 0.62
DYRK1A Q13627 1/20 0.62
PIM3 Q86V86 1/20 0.62
PIM2 Q9P1W9 1/20 0.62
GFER P55789 1/20 0.60
HSD17B10 Q99714 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31331777 0.82 MCL1 (0.70) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL11227296 0.81 MCL1 (0.68) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL7358800 0.80 MCL1 (0.67) MCL1MAOBGAAKDM4EALDH1A1
4-Methyldaphnetin SCHEMBL1065373 0.78 MCL1 (1.00) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL4187220 0.78 MAOB (1.00) MCL1MAOBGAAKDM4EALDH1A1
4-Methyldaphnetin SCHEMBL29671915 0.78 MCL1 (1.00) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL4929327 0.78 PIM1 (0.64) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL9996019 0.77 DYRK1A (1.00) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL27860821 0.77 MAOB (0.69) MCL1MAOBGAAKDM4EALDH1A1
SCHEMBL9643035 0.76 MAOB (0.62) MCL1MAOBGAAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4483376-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME García Sada, Fernando (MX) 2025-01-01 EP claimed
CN-118922890-A Measurement, diagnosis, treatment and management of metabolic syndrome 费尔南多·加西亚·萨达 2024-11-08 CN claimed
WO-2023161832-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME GARCIA SADA FERNANDO (MX) 2023-08-31 WO claimed
US-20230266340-A1 Measurement, Diagnosis, Treatment and Management of Metabolic Syndrome SILTI AG (CH) 2023-08-24 US claimed
US-7772334-B2 Crosslinker of reactive functional groups and nonionic metal coordinating structure-containing alkyl or aromatic compound BASF COATINGS GMBH (DE) 2010-08-10 US claimed
US-7759436-B2 Film-former of resin with nonionic metal coordinating structure and crosslinker-reactive group BASF COATINGS GMBH (DE) 2010-07-20 US claimed
EP-1575575-A2 SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY NOVO NORDISK A/S (DK) 2005-09-21 EP claimed
US-20040138301-A1 Chemical uncouplers for the treatment of obesity HIGH POINT PHARMACEUTICALS, LLC 2004-07-15 US claimed
WO-2004041256-A2 SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY NOVO NORDISK A/S (DK) 2004-05-21 WO claimed
EP-4483376-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME García Sada, Fernando (MX) 2025-01-01 EP disclosed
CN-118922890-A Measurement, diagnosis, treatment and management of metabolic syndrome 费尔南多·加西亚·萨达 2024-11-08 CN disclosed
US-20240066001-A1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES SILTI AG (CH) 2024-02-29 US disclosed
US-20240066001-A1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES SILTI AG (CH) 2024-02-29 US disclosed
EP-3164125-B1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES NAN GLOBAL LLC (US) 2023-09-06 EP disclosed
US-20040138301-A1 Chemical uncouplers for the treatment of obesity HIGH POINT PHARMACEUTICALS, LLC 2004-07-15 US disclosed
WO-2004041256-A2 SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY NOVO NORDISK A/S (DK) 2004-05-21 WO disclosed
WO-2004002953-A2 LACTONE COMPOUNDS, FOR USE AS ANTIOXIDANT AGENTS IN PHARMACEUTICAL, COSMETIC OR FOOD COMPOSITIONS COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 2004-01-08 WO disclosed
EP-0157384-B1 Substrates for hydrolases, process for their preparation and their use BIOMED LABORDIAGNOSTIK GMBH (DE) 1995-01-18 EP disclosed
US-4716222-A CHROMOGENS, SPECTROPHOTOMETRY HOECHST AKTIENGESELLSCHAFT (DE) 1987-12-29 US disclosed
EP-0157384-A2 Substrates for hydrolases, process for their preparation and their use Biomed Labordiagnostik GmbH (DE) 1985-10-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066001-A1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES GPR119, CPT1B, CPT2 MCL1 2566/4885MAOB 2481/4885GAA 3100/4885
US-20040138301-A1 Chemical uncouplers for the treatment of obesity PC, CPT2, IDH2 MCL1 776/4885MAOB 4393/4885GAA 2391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.