Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.35 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775195 | 0.78 | TRPV4 (0.37) | TRPV4RAD51CCR2CA1CA2 | |
| SCHEMBL1814581 | 0.78 | HSP90AA1 (0.43) | TRPV4TSHRHTTLMNACA1 | |
| SCHEMBL31470482 | 0.78 | HSP90AA1 (0.43) | TRPV4TSHRHTTLMNACA1 | |
| SCHEMBL4142707 | 0.77 | TSHR (0.54) | TRPV4TSHRHTTLMNAHPGD | |
| SCHEMBL31450141 | 0.77 | TSHR (0.54) | TRPV4TSHRHTTLMNAHPGD | |
| SCHEMBL31645086 | 0.75 | TRPV4 (0.39) | TRPV4TSHRHTTLMNAHPGD | |
| SCHEMBL31645221 | 0.75 | KMT2A (0.49) | TRPV4TSHRHTTCCR2CA1 | |
| SCHEMBL2927021 | 0.75 | TRPV4 (0.39) | TRPV4TSHRHTTLMNAHPGD | |
| SCHEMBL434170 | 0.75 | KMT2A (0.49) | TRPV4TSHRHTTCCR2CA1 | |
| SCHEMBL13799680 | 0.75 | TRPV4 (0.39) | TRPV4RAD51CCR2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015092713-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |
| WO-2011161201-A1 | BISARYLSULFONAMIDES USEFUL AS KINASE INHIBITORS IN THE TREATMENT OF INFLAMMATION AND CANCER | KANCERA AB (SE) | 2011-12-29 | — | — | WO | disclosed |