Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 2/20 | 0.46 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490860 | 1.00 | KDM4E (0.46) | KDM4EKDM5CPHF8KDM2ALMNA | |
| SCHEMBL22544587 | 0.92 | CA12 (0.46) | KDM4EKDM5CPHF8KDM2ALMNA | |
| SCHEMBL868533 | 0.90 | LMNA (0.52) | KDM4ELMNAALOX15ALDH1A1KMT2A | |
| SCHEMBL766363 | 0.89 | PHF8 (0.52) | KDM4EKDM5CPHF8KDM2ALMNA | |
| Trientine SCHEMBL505672 | 0.89 | LMNA (0.58) | KDM4EKDM5CPHF8KDM2ALMNA | |
| Trientine SCHEMBL506363 | 0.89 | LMNA (0.58) | KDM4EKDM5CPHF8KDM2ALMNA | |
| Succinic Acid SCHEMBL2447637 | 0.89 | LMNA (0.58) | KDM4EKDM5CPHF8KDM2ALMNA | |
| Trientine SCHEMBL14343015 | 0.89 | LMNA (0.58) | KDM4EKDM5CPHF8KDM2ALMNA | |
| SCHEMBL19524588 | 0.87 | CA5B (0.50) | KDM4ELMNATDP1CA12CA6 | |
| SCHEMBL12640030 | 0.87 | CA5B (0.50) | KDM4ELMNATDP1CA12CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395041-A1 | Polymers for delivery of nucleic acids | F. Hoffmann-La Roche AG (CH) | 2011-12-14 | — | — | EP | disclosed |