SCHEMBL490860

SCHEMBL490860

NCCNCCNC(=O)CCC(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.46
KDM5C P41229 2/20 0.46
PHF8 Q9UPP1 2/20 0.46
KDM2A Q9Y2K7 2/20 0.46
LMNA P02545 4/20 0.46
TDP1 Q9NUW8 2/20 0.46
CA12 O43570 2/20 0.46
CA6 P23280 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CA5B Q9Y2D0 2/20 0.46
ALOX15 P16050 2/20 0.46
ALDH1A1 P00352 2/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA5A P35218 1/20 0.46
TP53 P04637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9999327 1.00 KDM4E (0.46) KDM4EKDM5CPHF8KDM2ALMNA
SCHEMBL22544587 0.92 CA12 (0.46) KDM4EKDM5CPHF8KDM2ALMNA
SCHEMBL868533 0.90 LMNA (0.52) KDM4ELMNAALOX15ALDH1A1KMT2A
SCHEMBL766363 0.89 PHF8 (0.52) KDM4EKDM5CPHF8KDM2ALMNA
Trientine SCHEMBL505672 0.89 LMNA (0.58) KDM4EKDM5CPHF8KDM2ALMNA
Trientine SCHEMBL506363 0.89 LMNA (0.58) KDM4EKDM5CPHF8KDM2ALMNA
Succinic Acid SCHEMBL2447637 0.89 LMNA (0.58) KDM4EKDM5CPHF8KDM2ALMNA
Trientine SCHEMBL14343015 0.89 LMNA (0.58) KDM4EKDM5CPHF8KDM2ALMNA
SCHEMBL19524588 0.87 CA5B (0.50) KDM4ELMNATDP1CA12CA6
SCHEMBL12640030 0.87 CA5B (0.50) KDM4ELMNATDP1CA12CA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119161854-A POSS-based modified polyacrylate temperature-resistant adhesive, preparation method thereof and temperature-resistant protective film 浙江艾合新材料有限公司 2024-12-20 CN disclosed
US-20230288757-A1 INK COMPOSITIONS WITH QUANTUM DOT CONCENTRATIONS FOR DISPLAY DEVICES KATEEVA, INC. (US) 2023-09-14 US disclosed
US-20130136691-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS BRACCO IMAGING S.P.A. (IT) 2013-05-30 US disclosed
US-8444954-B2 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2013-05-21 US disclosed
US-8420053-B2 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2013-04-16 US disclosed
US-8420050-B2 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2013-04-16 US disclosed
EP-2500040-A1 Improved Gastrin Releasing Peptide Receptor-Binding Compounds Bracco Imaging S.p.A (IT) 2012-09-19 EP disclosed
US-20120178906-A1 CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES BRACCO IMAGING S.P.A. (IT) 2012-07-12 US disclosed
EP-1904460-B1 MULTIDENTATE AZA LIGANDS ABLE TO COMPLEX METAL IONS AND THE USE THEREOF IN DIAGNOSTICS AND THERAPY BRACCO IMAGING SPA (IT) 2012-05-16 EP disclosed
US-8105567-B2 Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy BRACCO IMAGING SPA (IT) 2012-01-31 US disclosed
EP-1898962-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS Bracco Imaging, S.P.A. (IT) 2008-03-19 EP disclosed
WO-2006136564-A9 MULTIDENTATE AZA LIGANDS ABLE TO COMPLEX METAL IONS AND THE USE THEREOF IN DIAGNOSTICS AND THERAPY BRACCO IMAGING SPA (IT) 2008-02-07 WO disclosed
US-20080008649-A1 Gastrin Releasing Peptide Compounds BRACCO IMAGING S.P.A. (IT) 2008-01-10 US disclosed
WO-2007109475-A2 CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES BRACCO IMAGING S.P.A. (IT) 2007-09-27 WO disclosed
WO-2007002500-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS BRACCO IMAGING S.P.A. (IT) 2007-01-04 WO disclosed
WO-2006136564-A1 MULTIDENTATE AZA LIGANDS ABLE TO COMPLEX METAL IONS AND THE USE THEREOF IN DIAGNOSTICS AND THERAPY BRACCO IMAGING S.P.A. (IT) 2006-12-28 WO disclosed
US-20060239914-A1 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2006-10-26 US disclosed
US-20060239923-A1 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2006-10-26 US disclosed
US-20060018830-A1 Gastrin releasing peptide compounds BRACCO IMAGING S.P.A. (IT) 2006-01-26 US disclosed
US-20040253225-A1 bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy BRACCO IMAGING S.P.A. (IT) 2004-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060239914-A1 Gastrin releasing peptide compounds GRPR, GIPR, CCKBR KDM4E 4725/4885KDM5C 4071/4885PHF8 3795/4885
US-20130136691-A1 GASTRIN RELEASING PEPTIDE COMPOUNDS GRPR, GIPR, GHRHR KDM4E 4862/4885KDM5C 4879/4885PHF8 4641/4885
US-20080008649-A1 Gastrin Releasing Peptide Compounds GRPR, SSTR5, GIPR KDM4E 4615/4885KDM5C 3832/4885PHF8 3196/4885
US-20040253225-A1 bombesin, derivatives and/or analogues capable of complexing metal ions, radionuclides or optical labels, for use in radiotherapy GRPR, MLNR, NPBWR1 KDM4E 4756/4885KDM5C 4204/4885PHF8 4042/4885
US-20060239923-A1 Gastrin releasing peptide compounds GRPR, GIPR, CCKBR KDM4E 4611/4885KDM5C 4430/4885PHF8 3937/4885
US-20060018830-A1 Gastrin releasing peptide compounds GRPR, GIPR, CCKBR KDM4E 4725/4885KDM5C 4071/4885PHF8 3795/4885
US-20120178906-A1 CHELATION OF METALS TO THIOL GROUPS USING IN SITU REDUCTION OF DISULFIDE-CONTAINING COMPOUNDS BY PHOSPHINES TST, PTMS, MPST KDM4E 4325/4885KDM5C 3882/4885PHF8 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.