Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12869192 | 0.88 | POLB (0.83) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 | |
| SCHEMBL9544841 | 0.83 | POLB (1.00) | POLBGAAALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2893384 | 0.75 | POLB (0.58) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 | |
| SCHEMBL486151 | 0.74 | GAA (1.00) | POLBGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12869177 | 0.73 | POLB (0.61) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 | |
| SCHEMBL8321902 | 0.73 | POLB (0.81) | POLBGAAALDH1A1HTTNPSR1 | |
| SCHEMBL20036913 | 0.70 | POLB (0.56) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 | |
| SCHEMBL7285810 | 0.69 | POLB (0.63) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 | |
| SCHEMBL7054325 | 0.68 | POLB (0.71) | POLBALDH1A1NPSR1MT-CO2MEN1 | |
| SCHEMBL17228373 | 0.67 | POLB (0.59) | POLBGAAALDH1A1SMN1; SMN2MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021363-A1 | Co-Crystals and Their Use | DATALASE LTD. (GB) | 2012-01-26 | — | — | US | disclosed |
| US-20120021363-A1 | Co-Crystals and Their Use | DATALASE LTD. (GB) | 2012-01-26 | — | — | US | disclosed |
| WO-2010089595-A1 | CO-CRYSTALS AND THEIR USE | DATALASE LTD. (GB) | 2010-08-12 | — | — | WO | disclosed |