Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.69 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | RGS12 | O14924 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Decanoic Acid SCHEMBL2370921 | 1.00 | ALDH1A1 (0.69) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Stearic Acid SCHEMBL2369752 | 1.00 | ALDH1A1 (0.69) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Decanoic Acid SCHEMBL2370923 | 1.00 | ALDH1A1 (0.69) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Linoleic Acid SCHEMBL15153134 | 0.91 | PPARG (0.59) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Linoleic Acid SCHEMBL15153131 | 0.91 | PPARG (0.59) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Racephedrine SCHEMBL8733657 | 0.90 | ALDH1A1 (0.67) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Pseudoephedrine SCHEMBL8733656 | 0.90 | ALDH1A1 (0.67) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Racephedrine SCHEMBL28507177 | 0.84 | CYP2D6 (0.76) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| Stearic Acid SCHEMBL10620295 | 0.83 | ALDH1A1 (0.60) | ALDH1A1ASAH1ACER2TSHRALOX15 | |
| SCHEMBL8340882 | 0.82 | ASAH1 (1.00) | ALDH1A1ASAH1ACER2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130203602-A1 | SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS | DANMARKS TEKNISKE UNIVERSITET (DK) | 2013-08-08 | — | — | US | disclosed |
| EP-2544664-A1 | SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS | Danmarks Tekniske Universitet (DK) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011110662-A1 | SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS | DANMARKS TEKNISKE UNIVERSITET (DK) | 2011-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203602-A1 | SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS | MIF, BMP2, BMP4 | ALDH1A1 2373/4885ASAH1 949/4885ACER2 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.