Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADSS2 | P30520 | 2/20 | 0.52 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.41 |
| ▸ | IGF2R | P11717 | 4/20 | 0.38 |
| ▸ | AMDHD2 | Q9Y303 | 1/20 | 0.38 |
| ▸ | PGD | P52209 | 1/20 | 0.38 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.37 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.37 |
| ▸ | UMPS | P11172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fructose 1,6-Diphosphate SCHEMBL166666 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL168245 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL168244 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL19133126 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fosfructose SCHEMBL20731194 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL28251436 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL31540134 | 1.00 | ADSS2 (0.52) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL21693672 | 0.98 | ADSS2 (0.51) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL21693701 | 0.98 | ADSS2 (0.51) | ADSS2FBP1P2RY14IGF2RAMDHD2 | |
| Fructose 1,6-Diphosphate SCHEMBL5805102 | 0.98 | ADSS2 (0.51) | ADSS2FBP1P2RY14IGF2RAMDHD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708267-B2 | Activators of human pyruvate kinase | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150183744-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | US HEALTH (US) | 2015-07-02 | — | — | US | disclosed |
| US-20130109672-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (US) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183744-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | PDK2, PDK1, PDK3 | ADSS2 464/4885FBP1 226/4885P2RY14 2486/4885 |
| US-20130109672-A1 | ACTIVATORS OF HUMAN PYRUVATE KINASE | PDK2, PDK1, PKLR | ADSS2 488/4885FBP1 281/4885P2RY14 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.