Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | CDC25B | P30305 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | APAF1 | O14727 | 6/20 | 0.46 |
| ▸ | CASP3 | P42574 | 5/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | UBE2I | P63279 | 2/20 | 0.46 |
| ▸ | GALK1 | P51570 | 1/20 | 0.46 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751000 | 1.00 | LOXL2 (0.54) | LOXL2KDM4EGAACDC25BALDH1A1 | |
| SCHEMBL29430150 | 0.84 | HPGD (0.62) | LOXL2KDM4EGAACDC25BALDH1A1 | |
| SCHEMBL2815600 | 0.84 | HPGD (0.62) | LOXL2KDM4EGAACDC25BALDH1A1 | |
| SCHEMBL30853483 | 0.78 | KDM4E (0.53) | LOXL2KDM4EGAACDC25BALDH1A1 | |
| SCHEMBL1872809 | 0.78 | KDM4E (0.53) | LOXL2KDM4EGAACDC25BALDH1A1 | |
| SCHEMBL16008410 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4002866 | 0.77 | MAP2K1 (0.35) | LOXL2KDM4EGAAPARP1 | |
| SCHEMBL29362757 | 0.76 | FLT3 (0.71) | KDM4EGAAALDH1A1HPGDMAPT | |
| SCHEMBL118686 | 0.76 | FLT3 (0.71) | KDM4EGAAALDH1A1HPGDMAPT | |
| SCHEMBL717595 | 0.74 | KIF11 (0.44) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107434782-B | A kind of synthetic method of 4- oxyquinoline ketone derivatives and its application in antitumor research | 重庆文理学院 | 2019-11-05 | — | — | CN | disclosed |
| US-8618129-B2 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| US-8618129-B2 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| US-8618129-B2 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| JP-2013536808-A | — | — | 2013-09-26 | — | — | JP | disclosed |
| EP-2611780-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| EP-2611780-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028300-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028300-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | KCNQ1, KCNQ2, KCNQ3 | LOXL2 3892/4885KDM4E 459/4885GAA 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.