ATP12A

Potassium-transporting ATPase alpha chain 2 · P54707 · ATP12A on Sugi Atlas →

5,248 patent compounds predicted against ATP12A, 4,006 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cassaine (SCHEMBL4167834)	1.00	6/20
Cassaine (SCHEMBL4167835)	1.00	6/20
SCHEMBL677461	0.84	6/20
SCHEMBL3134704	0.69	5/20
Istaroxime (SCHEMBL1427268)	1.00	4/20
Istaroxime (SCHEMBL1427271)	1.00	4/20
Istaroxime (SCHEMBL1427274)	1.00	4/20
Hydrochloric Acid (SCHEMBL3652682)	0.98	4/20
Hydrochloric Acid (SCHEMBL3652685)	0.98	4/20
Istaroxime (SCHEMBL1115669)	0.98	4/20
Istaroxime (SCHEMBL1115671)	0.98	4/20
Istaroxime (SCHEMBL1115673)	0.98	4/20
Istaroxime (SCHEMBL3347159)	0.98	4/20
Istaroxime (SCHEMBL3347161)	0.98	4/20
SCHEMBL2793200	0.82	4/20
SCHEMBL4661150	0.82	4/20
SCHEMBL4661154	0.82	4/20
SCHEMBL4661158	0.82	4/20
Hydrochloric Acid (SCHEMBL4662189)	0.80	4/20
Hydrochloric Acid (SCHEMBL4662194)	0.80	4/20

Clinical trials — most relevant to ATP12A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma	PHASE4	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
Calcium Electroporation for Head and Neck Cancer	PHASE1	UNKNOWN
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy	nan	COMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Pharmacogenetics and Cardiovascular Events	nan	COMPLETED
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Signs and Symptoms of Genetic Abnormalities Linked to Inherited Heart Disease	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Core Stability Exercises and Hereditary Ataxia	nan	COMPLETED
Characteristics of Nondystrophic Myotonias	nan	COMPLETED
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP12A binder may also engage these)

Protein	Name	Similarity
Q64392	—	1.000	Q64392 →
P54708	—	0.999	P54708 →
Q9TV52	—	0.999	Q9TV52 →
Q92036	—	0.998	Q92036 →
Q9Z1W8	—	0.997	Q9Z1W8 →
ATP4A	Potassium-transporting ATPase alpha chain 1 (	0.997	landscape →
Q92126	—	0.994	Q92126 →
Q9WV27	—	0.993	Q9WV27 →
P17326	—	0.992	P17326 →
P09626	—	0.992	P09626 →
P50997	—	0.991	P50997 →
Q64541	—	0.990	Q64541 →
P27112	—	0.990	P27112 →
P50996	—	0.990	P50996 →
ATP1A4	Sodium/potassium-transporting ATPase subunit	0.989	landscape →
P05025	—	0.989	P05025 →
Q64436	—	0.988	Q64436 →
P19156	—	0.988	P19156 →
Q9N0Z6	—	0.988	Q9N0Z6 →
P35317	—	0.987	P35317 →
P58312	—	0.987	P58312 →
P04074	—	0.987	P04074 →
Q6RWA9	—	0.986	Q6RWA9 →
P25489	—	0.986	P25489 →
P30714	—	0.985	P30714 →
Q9YH26	—	0.985	Q9YH26 →
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	0.985	landscape →
P09572	—	0.984	P09572 →
P28774	—	0.984	P28774 →
Q7PPA5	—	0.984	Q7PPA5 →