ATP1A4

Sodium/potassium-transporting ATPase subunit · Q13733 · ATP1A4 on Sugi Atlas →

17,525 patent compounds predicted against ATP1A4, 10,073 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
SCHEMBL1484406	0.65	14/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20
Ramnodigin (SCHEMBL1812161)	0.84	12/20
Actodigin (SCHEMBL122586)	0.74	12/20
SCHEMBL1483283	0.66	12/20
SCHEMBL714901	0.63	12/20
SCHEMBL2258970	0.63	12/20
SCHEMBL2256038	0.61	12/20
SCHEMBL2256162	0.61	12/20
SCHEMBL2256169	0.61	12/20
SCHEMBL255971	0.60	12/20
SCHEMBL716452	0.60	12/20
SCHEMBL174232	0.59	12/20
SCHEMBL256803	0.59	12/20

Clinical trials — most relevant to ATP1A4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Switching From Insulin to Sulfonylurea in Diabetes Associated With Variants in MODY Genes	PHASE4	UNKNOWN
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer	PHASE3	COMPLETED
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels	PHASE3	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Copper Histidine Therapy for Menkes Diseases	PHASE1/PHASE2	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	nan	RECRUITING
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.	nan	NOT_YET_RECRUITING
Gene Study for Infantile Onset Diabetes	nan	UNKNOWN
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Role for Biochemical Assays and Kayser-Fleischer Rings in Diagnosis of Wilson Disease	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ATP1A4 binder may also engage these)

Protein	Name	Similarity
P50997	—	1.000	P50997 →
P05025	—	1.000	P05025 →
P25489	—	1.000	P25489 →
Q9N0Z6	—	1.000	Q9N0Z6 →
Q08DA1	—	1.000	Q08DA1 →
P04074	—	1.000	P04074 →
Q92030	—	1.000	Q92030 →
Q8VDN2	—	1.000	Q8VDN2 →
ATP1A2	Sodium/potassium-transporting ATPase subunit	0.999	landscape →
Q9WV27	—	0.999	Q9WV27 →
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	0.999	landscape →
A2VDL6	—	0.998	A2VDL6 →
P05024	—	0.998	P05024 →
P17326	—	0.998	P17326 →
P30714	—	0.998	P30714 →
P13607	—	0.997	P13607 →
P09572	—	0.997	P09572 →
D2WKD8	—	0.997	D2WKD8 →
Q9YH26	—	0.997	Q9YH26 →
P58312	—	0.997	P58312 →
P06685	—	0.997	P06685 →
Q92123	—	0.997	Q92123 →
Q6RWA9	—	0.997	Q6RWA9 →
Q5RDR3	—	0.997	Q5RDR3 →
Q64541	—	0.996	Q64541 →
P18907	—	0.996	P18907 →
ATP1A3	Sodium/potassium-transporting ATPase subunit	0.995	landscape →
Q5RCD8	—	0.994	Q5RCD8 →
P06687	—	0.994	P06687 →
P28774	—	0.994	P28774 →