ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1 · P05026 · ATP1B1 on Sugi Atlas →

17,766 patent compounds predicted against ATP1B1, 10,232 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Metildigoxin (SCHEMBL43349)	0.89	16/20
Digoxin (SCHEMBL20506)	1.00	15/20
Digoxin (SCHEMBL126382)	1.00	15/20
Digoxin (SCHEMBL428012)	1.00	15/20
Digoxin (SCHEMBL597821)	0.94	15/20
Digoxin (SCHEMBL1559560)	0.94	15/20
Digoxin (SCHEMBL1584137)	0.93	15/20
Digoxin (SCHEMBL1461589)	0.58	15/20
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
Digoxin (SCHEMBL1830809)	0.91	14/20
SCHEMBL1302063	0.85	14/20
SCHEMBL1484406	0.65	14/20
Deslanoside (SCHEMBL125311)	0.80	13/20
Deslanoside (SCHEMBL125312)	0.80	13/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20

Clinical trials — most relevant to ATP1B1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers	PHASE1	UNKNOWN
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Analysis of Genes That Predispose People to Develop High Blood Pressure	nan	COMPLETED
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Diagnosis of Primary Ciliary Dyskinesia	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma	nan	UNKNOWN
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Mapping Disease Pathways for Biliary Atresia	nan	RECRUITING
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis	nan	RECRUITING
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP1B1 binder may also engage these)

Protein	Name	Similarity
Q5R8S8	—	1.000	Q5R8S8 →
P07340	—	1.000	P07340 →
Q9TT37	—	1.000	Q9TT37 →
P05028	—	1.000	P05028 →
A5A6J8	—	1.000	A5A6J8 →
P05027	—	1.000	P05027 →
Q4R4V5	—	1.000	Q4R4V5 →
Q9JM72	—	0.999	Q9JM72 →
P14094	—	0.997	P14094 →
P06583	—	0.997	P06583 →
P08251	—	0.997	P08251 →
P13638	—	0.993	P13638 →
P51165	—	0.992	P51165 →
Q28030	—	0.991	Q28030 →
ATP1B2	Sodium/potassium-transporting ATPase subunit	0.991	landscape →
Q8WMG3	—	0.990	Q8WMG3 →
P14231	—	0.990	P14231 →
Q5J583	—	0.988	Q5J583 →
Q2HZ96	—	0.987	Q2HZ96 →
P30715	—	0.986	P30715 →
Q24048	—	0.982	Q24048 →
Q9I9C3	—	0.978	Q9I9C3 →
P05029	—	0.977	P05029 →
P21188	—	0.968	P21188 →
Q202B1	—	0.967	Q202B1 →
Q5F362	—	0.965	Q5F362 →
P18597	—	0.963	P18597 →
Q8VEK0	—	0.963	Q8VEK0 →
P33704	—	0.962	P33704 →
Q17QL5	—	0.961	Q17QL5 →