ATP1B2

Sodium/potassium-transporting ATPase subunit · P14415 · ATP1B2 on Sugi Atlas →

17,756 patent compounds predicted against ATP1B2, 10,228 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Metildigoxin (SCHEMBL43349)	0.89	16/20
Digoxin (SCHEMBL20506)	1.00	15/20
Digoxin (SCHEMBL126382)	1.00	15/20
Digoxin (SCHEMBL428012)	1.00	15/20
Digoxin (SCHEMBL597821)	0.94	15/20
Digoxin (SCHEMBL1559560)	0.94	15/20
Digoxin (SCHEMBL1584137)	0.93	15/20
Digoxin (SCHEMBL1461589)	0.58	15/20
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
Digoxin (SCHEMBL1830809)	0.91	14/20
SCHEMBL1302063	0.85	14/20
SCHEMBL1484406	0.65	14/20
Deslanoside (SCHEMBL125311)	0.80	13/20
Deslanoside (SCHEMBL125312)	0.80	13/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20

Clinical trials — most relevant to ATP1B2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
PHOspholamban RElated CArdiomyopathy STudy - Intervention	PHASE3	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome	nan	RECRUITING
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Cross-sectional and Prospective Study to Characterize Early-onset Presbycusis	nan	RECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients	nan	ACTIVE_NOT_RECRUITING
Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions	nan	WITHDRAWN
New Biomarkers and Difficult-to-treat Hypertension	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Clinical and Genetic Examinations of Dilated Cardiomyopathy	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Feasibility of Improving Risk Stratification in Brugada Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP1B2 binder may also engage these)

Protein	Name	Similarity
P13638	—	1.000	P13638 →
Q8WMG3	—	1.000	Q8WMG3 →
Q28030	—	1.000	Q28030 →
Q5J583	—	1.000	Q5J583 →
P14231	—	1.000	P14231 →
Q9TT37	—	0.994	Q9TT37 →
P05028	—	0.993	P05028 →
Q9JM72	—	0.993	Q9JM72 →
P07340	—	0.993	P07340 →
P08251	—	0.993	P08251 →
ATP1B1	Sodium/potassium-transporting ATPase subunit beta-1	0.991	landscape →
Q5R8S8	—	0.990	Q5R8S8 →
P05027	—	0.990	P05027 →
Q4R4V5	—	0.989	Q4R4V5 →
A5A6J8	—	0.989	A5A6J8 →
P51165	—	0.988	P51165 →
P14094	—	0.988	P14094 →
Q2HZ96	—	0.987	Q2HZ96 →
P30715	—	0.987	P30715 →
Q24048	—	0.987	Q24048 →
P06583	—	0.986	P06583 →
Q9I9C3	—	0.977	Q9I9C3 →
P05029	—	0.975	P05029 →
P18597	—	0.974	P18597 →
Q202B1	—	0.972	Q202B1 →
Q5F362	—	0.971	Q5F362 →
P21188	—	0.971	P21188 →
ATP4B	Potassium-transporting ATPase subunit beta (G	0.971	landscape →
P33704	—	0.970	P33704 →
Q8VEK0	—	0.970	Q8VEK0 →