Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BRPF1 | P55201 | 6/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | BRD1 | O95696 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.53 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.53 |
| ▸ | TAF1 | P21675 | 1/20 | 0.53 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.53 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533514 | 0.90 | RAB9A (0.51) | MAPTNPC1RAB9AAHRGFER | |
| SCHEMBL533977 | 0.87 | GAA (0.57) | MAPTRAB9AGFERPOLBKMT2A | |
| SCHEMBL532973 | 0.87 | MAPT (0.44) | MAPTNPC1RAB9AAHRGFER | |
| SCHEMBL533064 | 0.87 | MAPT (0.56) | MAPTNPC1RAB9ASMN1; SMN2BRPF1 | |
| SCHEMBL532963 | 0.85 | SGMS2 (0.52) | NPC1SMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL534076 | 0.85 | POLB (0.53) | MAPTNPC1RAB9AGFERSMN1; SMN2 | |
| SCHEMBL532801 | 0.84 | GAA (0.48) | MAPTNPC1RAB9ASMN1; SMN2BRPF1 | |
| SCHEMBL532950 | 0.84 | KMT2A (0.56) | MAPTNPC1RAB9ASMN1; SMN2BRPF1 | |
| SCHEMBL532964 | 0.84 | L3MBTL1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2BRPF1 | |
| SCHEMBL532983 | 0.83 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |