Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 4/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 15/20 | 0.45 |
| ▸ | CACNB4 | O00305 | 11/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 11/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 11/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 11/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 11/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 11/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 11/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 11/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 11/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 11/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 11/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 11/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 11/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 11/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 11/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 11/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 11/20 | 0.45 |
| ▸ | CACNA2D3 | Q8IZS8 | 11/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116352 | 0.77 | MARS1 (1.00) | MARS1 | |
| SCHEMBL116345 | 0.77 | MARS1 (1.00) | MARS1 | |
| SCHEMBL2721346 | 0.70 | ALDH1A1 (0.64) | MARS1 | |
| SCHEMBL15781023 | 0.69 | CACNA1B (0.60) | MARS1CACNA1BCACNB4CACNA1ACACNA1G | |
| SCHEMBL11117017 | 0.63 | NOTUM (0.56) | MARS1 | |
| SCHEMBL15781857 | 0.63 | CACNB4 (0.80) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL15772247 | 0.63 | CACNA1B (0.58) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL15781864 | 0.63 | CACNB4 (0.77) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL15770960 | 0.62 | CACNB4 (1.00) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 | |
| Hydrochloric Acid SCHEMBL15770918 | 0.62 | CACNB4 (0.76) | CACNA1BCACNB4CACNA1ACACNA1GCACNG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | AARS1, GARS1, TRMT1 | MARS1 55/4885CACNA1B 4829/4885CACNB4 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.