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Sugi Predict / Targets / CARS1

CARS1

Cysteine--tRNA ligase, cytoplasmic · P49589 · CARS1 on Sugi Atlas →

3,786 patent compounds predicted against CARS1, 3,470 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Icotinib Icotinib (SCHEMBL5843603) 1.00 1/20
Osimertinib Osimertinib (SCHEMBL14660911) 1.00 1/20
Osimertinib Osimertinib (SCHEMBL14661152) 0.95 1/20
SCHEMBL14719686 SCHEMBL14719686 0.88 1/20
SCHEMBL14661086 SCHEMBL14661086 0.87 1/20
SCHEMBL17683216 SCHEMBL17683216 0.86 1/20
SCHEMBL17553467 SCHEMBL17553467 0.85 1/20
SCHEMBL17553471 SCHEMBL17553471 0.85 1/20
SCHEMBL17553693 SCHEMBL17553693 0.84 1/20
SCHEMBL17683059 SCHEMBL17683059 0.84 1/20
SCHEMBL17683065 SCHEMBL17683065 0.84 1/20
SCHEMBL17553560 SCHEMBL17553560 0.84 1/20
SCHEMBL17553469 SCHEMBL17553469 0.83 1/20
SCHEMBL17373145 SCHEMBL17373145 0.83 1/20
SCHEMBL17553559 SCHEMBL17553559 0.83 1/20
SCHEMBL17683061 SCHEMBL17683061 0.83 1/20
SCHEMBL17683066 SCHEMBL17683066 0.83 1/20
SCHEMBL17683258 SCHEMBL17683258 0.83 1/20
SCHEMBL14670872 SCHEMBL14670872 0.83 1/20
SCHEMBL17373170 SCHEMBL17373170 0.82 1/20

Clinical trials — most relevant to CARS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis PHASE4COMPLETED
Reverse Transcriptase Inhibitors in AGS PHASE2COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN
Impact of Seasonal Malaria Chemoprevention on Immunity Against Malaria Among Children in Northern Benin nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease nanRECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Quantification of GADD34 Expression in RA nanCOMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Diagnosis of Primary Ciliary Dyskinesia nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Genomic of CONgenital Sideroblastic Anemias nanRECRUITING
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Genetics of Primary Ciliary Dyskinesia nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a CARS1 binder may also engage these)

ProteinNameSimilarity
Q5M7N8 — 1.000 Q5M7N8 →
Q4R550 — 1.000 Q4R550 →
Q5F408 — 1.000 Q5F408 →
Q9ER72 — 0.999 Q9ER72 →
Q291L4 — 0.996 Q291L4 →
Q7ZWR2 — 0.995 Q7ZWR2 →
Q09860 — 0.993 Q09860 →
Q7KN90 — 0.993 Q7KN90 →
Q7SIA2 — 0.992 Q7SIA2 →
Q6DJ95 — 0.991 Q6DJ95 →
KDM5B Lysine-specific demethylase 5B 0.990 landscape →
DHX29 ATP-dependent RNA helicase DHX29 0.990 landscape →
EPRS1 Bifunctional glutamate/proline--tRNA ligase 0.990 landscape →
Q5JPH6 — 0.990 Q5JPH6 →
Q54KR1 — 0.989 Q54KR1 →
Q8CGC7 — 0.989 Q8CGC7 →
P28350 — 0.989 P28350 →
P49696 — 0.989 P49696 →
A3KMI0 — 0.989 A3KMI0 →
Q6PGC1 — 0.989 Q6PGC1 →
Q9H1H9 — 0.989 Q9H1H9 →
KAT8 Histone acetyltransferase KAT8 0.989 landscape →
KDM5D Lysine-specific demethylase 5D 0.988 landscape →
KDM1A Lysine-specific histone demethylase 1A 0.988 landscape →
Q5XI06 — 0.988 Q5XI06 →
A7MBC2 — 0.988 A7MBC2 →
Q5RA20 — 0.988 Q5RA20 →
Q8BJM7 — 0.988 Q8BJM7 →
P41230 — 0.988 P41230 →
Q6PA41 — 0.988 Q6PA41 →