CASP12 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3758852	1.00	1/20
SCHEMBL4074929	0.73	1/20
SCHEMBL13056961	0.69	1/20
SCHEMBL3755750	0.69	1/20
SCHEMBL3758053	0.69	1/20
SCHEMBL13056963	0.69	1/20
SCHEMBL13056957	0.67	1/20
SCHEMBL3112121	0.66	1/20
Verubulin (SCHEMBL2232326)	0.64	1/20
SCHEMBL3118902	0.64	1/20
SCHEMBL13082149	0.64	1/20
Verubulin (SCHEMBL29379614)	0.64	1/20
SCHEMBL3759277	0.64	1/20
SCHEMBL2256527	0.63	1/20
SCHEMBL2257339	0.63	1/20
Verubulin (SCHEMBL2395194)	0.63	1/20
SCHEMBL3113583	0.63	1/20
SCHEMBL3115251	0.63	1/20
Verubulin (SCHEMBL29505369)	0.63	1/20
SCHEMBL13057013	0.62	1/20

Clinical trials — most relevant to CASP12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study to Evaluate the Safety and Efficacy of Secukinumab 300 mg and 150 mg in Adult Patients With Active Psoriatic Arthritis (PsA) After 16 Weeks of Treatment Compared to Placebo	PHASE4	COMPLETED
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
IBI112 in Moderate to Severe Plaque Psoriasis With Randomized Withdrawal and Re-treatment	PHASE3	COMPLETED
Gene Therapy in Treating Patients With Unresectable, Recurrent, or Refractory Head and Neck Cancer	PHASE1/PHASE2	COMPLETED
Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD	PHASE1/PHASE2	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Safety and Efficacy Study of a Caspase Inhibitor in Patients Undergoing Liver Transplantation	PHASE2	COMPLETED
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
A Study of (Interleukin-12) IL-12 in Patients With Acute Myelogenous Leukemia (AML)	PHASE1	ACTIVE_NOT_RECRUITING
Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma	PHASE1	RECRUITING
Interleukin-12 in Treating Patients With Advanced Cancer	PHASE1	COMPLETED
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors	PHASE1	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Mechanisms Relating to the Distinct in Vitro Susceptibility of Human Macrophages to L. Viannia Infection	nan	COMPLETED
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CASP12 binder may also engage these)

Protein	Name	Similarity
Q075B4	—	0.987	Q075B4 →
Q153Z0	—	0.987	Q153Z0 →
CASP5	Caspase-5	0.982	landscape →
Q920D5	—	0.976	Q920D5 →
O08736	—	0.974	O08736 →
CASP4	Caspase-4	0.974	landscape →
P70343	—	0.974	P70343 →
O75601	—	0.970	O75601 →
P29452	—	0.969	P29452 →
Q5E9C1	—	0.965	Q5E9C1 →
P43527	—	0.964	P43527 →
Q9MZV7	—	0.943	Q9MZV7 →
Q9MZV6	—	0.942	Q9MZV6 →
CASP1	Caspase-1	0.942	landscape →
Q9N2I1	—	0.938	Q9N2I1 →
Q4AC99	—	0.936	Q4AC99 →
CASP8	Caspase-8	0.935	landscape →
Q9JHX4	—	0.935	Q9JHX4 →
O89110	—	0.935	O89110 →
Q9I9L7	—	0.934	Q9I9L7 →
Q9TV13	—	0.931	Q9TV13 →
Q3UX83	—	0.930	Q3UX83 →
P55866	—	0.929	P55866 →
P0DOV2	—	0.928	P0DOV2 →
O14977	—	0.928	O14977 →
Q569R5	—	0.927	Q569R5 →
Q9H1B4	—	0.927	Q9H1B4 →
Q99P81	—	0.927	Q99P81 →
O35368	—	0.926	O35368 →
Q8R455	—	0.926	Q8R455 →