Radafaxine

Radafaxine

SCHEMBL48964

C[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 20/20 1.00
SLC6A2 P23975 20/20 1.00
CHRNB4 P30926 20/20 1.00
CHRNA3 P32297 20/20 1.00
CHRNA4 P43681 20/20 1.00
SLC6A3 Q01959 19/20 1.00
CHRNA1 P02708 19/20 1.00
CHRNB1 P11230 19/20 1.00
CHRNG P07510 18/20 1.00
CHRND Q07001 18/20 1.00
SLC6A4 P31645 10/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Radafaxine SCHEMBL30486031 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL29751668 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL29465705 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL3453827 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL2599138 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL13014841 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL3453734 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL14521595 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL5478077 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
Radafaxine SCHEMBL3154016 1.00 CHRNB2 (1.00) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1291 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083709-A1 COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA APNIMED INC DELAWARE (US) 2026-03-26 US claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-20260027070-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED INC DELAWARE (US) 2026-01-29 US claimed
US-20250325510-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APRIMED INC DELAWARE (US) 2025-10-23 US claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
US-20250186371-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED, INC. (DELAWARE) 2025-06-12 US claimed
US-20250114321-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED, INC. (DELAWARE) 2025-04-10 US claimed
CN-119789855-A Methods and compositions for treating sleep apnea 爱普宁公司(特拉华) 2025-04-08 CN claimed
US-20250049803-A1 COMBINATION OF A TASK1/3 CHANNEL BLOCKER WITH A NOREPINEPHRINE REUPTAKE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA BAYER AKTIENGESELLSCHAFT (DE) 2025-02-13 US claimed
US-20250049779-A1 COMBINATION OF AN A2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A NOREPINEPHRINE REUPTAKE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA BAYER AKTIENGESELLSCHAFT (DE) 2025-02-13 US claimed
US-20030083330-A1 Pharmaceutically active morpholinol SMITHKLINE BEECHAM CORPORATION 2003-05-01 US claimed
US-20030064988-A1 Pharmaceutically active morpholinol SMITHKLINE BEECHAM CORPORATION 2003-04-03 US claimed
US-20030032643-A1 Pharmaceutically active morpholinol SMITHKLINE BEECHAM CORPORATION 2003-02-13 US claimed
WO-2002094323-A1 WEIGHT REDUCTION OR WEIGHT CONTROLLING COMPOSITION GLAXO GROUP LIMITED (GB) 2002-11-28 WO claimed
US-20020147196-A1 Composition and method for treating neuropathic pain GLAXO GROUP LIMITED (GB) 2002-10-10 US claimed
US-6391875-B2 Pharmaceutically active morpholinol SMITHKLINE BEECHAM CORPORATION 2002-05-21 US claimed
US-20020019396-A1 Pharmaceutically active morpholinol MORGAN PHILLIP FREDERICK (US) 2002-02-14 US claimed
US-6274579-B1 ANTIDEPRESSANTS, ANALGESICS; SEXUAL DISORDERS, ATTENTION DEFICIT DISORDER; DRUG ADDICTION; PARKINSON*S AND ALZHEIMER*S DISEASE; HEADACHES, OBESITY GLAXO WELLCOME INC. 2001-08-14 US claimed
EP-1047428-A1 PHARMACEUTICALLY ACTIVE MORPHOLINOL GLAXO GROUP LIMITED (GB) 2000-11-02 EP claimed
WO-1999037305-A1 PHARMACEUTICALLY ACTIVE MORPHOLINOL GLAXO GROUP LIMITED (GB) 1999-07-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027070-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA NTSR1, NTSR2, GPR39 CHRNB2 159/4885SLC6A2 6/4885CHRNB4 81/4885
US-20030032643-A1 Pharmaceutically active morpholinol ACHE, MGLL, COMT CHRNB2 105/4885SLC6A2 119/4885CHRNB4 78/4885
US-20260083709-A1 COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA CHRNA2, CHRNA3, ADRA2B CHRNB2 25/4885SLC6A2 4/4885CHRNB4 35/4885
US-20250114321-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA HCRTR2, CHRM3, CHRM2 CHRNB2 82/4885SLC6A2 164/4885CHRNB4 75/4885
US-20250049779-A1 COMBINATION OF AN A2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A NOREPINEPHRINE REUPTAKE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA ADRA2C, ADRB2, ADRA2A CHRNB2 19/4885SLC6A2 12/4885CHRNB4 43/4885
US-20250325510-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA HCRTR2, CHRM3, CHRM2 CHRNB2 82/4885SLC6A2 164/4885CHRNB4 75/4885
US-20250049803-A1 COMBINATION OF A TASK1/3 CHANNEL BLOCKER WITH A NOREPINEPHRINE REUPTAKE INHIBITOR FOR THE TREATMENT OF SLEEP APNEA SLC6A2, SLC6A3, ADRB3 CHRNB2 77/4885SLC6A2 1/4885CHRNB4 62/4885
US-20030083330-A1 Pharmaceutically active morpholinol ACHE, OPRL1, MGLL CHRNB2 80/4885SLC6A2 84/4885CHRNB4 57/4885
US-20020019396-A1 Pharmaceutically active morpholinol ACHE, COMT, OPRL1 CHRNB2 74/4885SLC6A2 67/4885CHRNB4 54/4885
US-20030064988-A1 Pharmaceutically active morpholinol ACHE, COMT, OPRL1 CHRNB2 74/4885SLC6A2 72/4885CHRNB4 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.