Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP4B1 | P13584 | 3/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.47 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.47 |
| ▸ | CYP2A7 | P20853 | 3/20 | 0.47 |
| ▸ | CYP3A7 | P24462 | 3/20 | 0.47 |
| ▸ | CYP2F1 | P24903 | 3/20 | 0.47 |
| ▸ | CYP2C18 | P33260 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17555617 | 0.89 | FYN (0.44) | FYNCYP1A1CYP1B1CYP1A2CYP2E1 | |
| SCHEMBL4938505 | 0.85 | DYRK1A (0.54) | FYNGAAMAPTNOS3NOS2 | |
| SCHEMBL1823930 | 0.84 | DYRK1A (0.53) | FYNCYP1A2CYP3A4CYP2D6MAPT | |
| SCHEMBL29092217 | 0.74 | HSP90AA1 (0.50) | FYNNOS3NOS2NOS1DYRK1A | |
| SCHEMBL13506871 | 0.73 | NOS3 (0.41) | FYNNOS3NOS2 | |
| SCHEMBL2603522 | 0.72 | FYN (0.43) | FYNCYP1A1CYP1B1CYP1A2CYP2E1 | |
| SCHEMBL13730604 | 0.71 | NOS3 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL17555709 | 0.70 | ADORA2A (0.41) | MAPT | |
| SCHEMBL1126240 | 0.70 | ABL1 (0.44) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL31648381 | 0.70 | FGFR1 (0.55) | FYNCYP1A1CYP1B1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058289-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO SA (CH) | 2011-11-15 | — | — | US | disclosed |
| EP-1786812-B1 | PYRIDINE METHYLENE AZOLIDINONES AND THEIR USE AS PHOSPHOINOSITIDE INHIBITORS | MERCK SERONO SA (CH) | 2011-11-09 | — | — | EP | disclosed |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | PIK3CD, PIK3CA, PTEN | FYN 109/4885CYP1A1 1483/4885CYP1B1 579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.