DUOX1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2027831	1.00	1/20
SCHEMBL29368383	1.00	1/20
SCHEMBL4923550	0.80	1/20
SCHEMBL4920436	0.78	1/20
SCHEMBL4928536	0.73	1/20
SCHEMBL4920666	0.71	1/20
SCHEMBL15313075	0.69	1/20
SCHEMBL4920220	0.69	1/20
SCHEMBL4928611	0.68	1/20
SCHEMBL17210872	0.67	1/20
SCHEMBL4937076	0.66	1/20
SCHEMBL29490371	0.66	1/20
SCHEMBL16560732	0.63	1/20
SCHEMBL4941814	0.60	1/20
SCHEMBL4918509	0.57	1/20
SCHEMBL4930461	0.57	1/20
SCHEMBL23585073	0.47	1/20

Clinical trials — most relevant to DUOX1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.	PHASE1/PHASE2	COMPLETED
Effects of Febuxostat for Lowering Uric Acid in NAFLD Patients With Gout	PHASE2	UNKNOWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
NOX-100 for Preventing Hypotension During Hemodialysis	PHASE2	COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers	PHASE1	COMPLETED
Endometriosis and Microvascular Dysfunction: Role of Inflammation	EARLY_PHASE1	RECRUITING
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings	nan	NOT_YET_RECRUITING
Mechanisms of Action of Acetaminophen	nan	COMPLETED
Sex-specific Association With Kidney Disease	nan	COMPLETED
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns	nan	COMPLETED
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19	nan	COMPLETED
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Neutrophil Oxidative Burst in Early and Late Onset Pediatric Inflammatory Bowel Disease	nan	UNKNOWN
Lung Mucus Hypersecretion and NQO1	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Redox Determinants of Severe Asthma (a Substudy of the Severe Asthma Research Program)	nan	COMPLETED
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN	nan	COMPLETED
Chronic Obstructive Pulmonary Disease Gene Localization	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DUOX1 binder may also engage these)

Protein	Name	Similarity
Q8HZK3	—	1.000	Q8HZK3 →
DUOX2	Dual oxidase 2	1.000	landscape →
Q8HZK2	—	1.000	Q8HZK2 →
Q9MZF4	—	1.000	Q9MZF4 →
A2AQ92	—	1.000	A2AQ92 →
Q8CIY2	—	0.998	Q8CIY2 →
Q9ES45	—	0.998	Q9ES45 →
O95479	—	0.979	O95479 →
Q9VQH2	—	0.974	Q9VQH2 →
MAP4K2	Mitogen-activated protein kinase kinase kinase kinase 2	0.973	landscape →
Q5NDF0	—	0.972	Q5NDF0 →
ABHD16A	Phosphatidylserine lipase ABHD16A	0.971	landscape →
Q8C6B2	—	0.971	Q8C6B2 →
P09531	—	0.971	P09531 →
I3L5V6	—	0.971	I3L5V6 →
P59240	—	0.970	P59240 →
Q9ULE6	—	0.970	Q9ULE6 →
Q8R4K8	—	0.970	Q8R4K8 →
ATP6AP1	V-type proton ATPase subunit S1	0.970	landscape →
Q8R2H5	—	0.969	Q8R2H5 →
Q502B3	—	0.969	Q502B3 →
Q1JPD2	—	0.969	Q1JPD2 →
Q400G9	—	0.969	Q400G9 →
Q8MIU0	—	0.969	Q8MIU0 →
Q5RJL6	—	0.969	Q5RJL6 →
O35385	—	0.969	O35385 →
Q8TE68	—	0.968	Q8TE68 →
Q2KIY5	—	0.968	Q2KIY5 →
Q5VV41	—	0.968	Q5VV41 →
Q8K099	—	0.968	Q8K099 →