SCHEMBL29490371

SCHEMBL29490371

c1ccc(Cn2nnc3c(Sc4ncco4)ncnc32)cc1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CYBB P04839 1/20 0.66
▸ NOX5 Q96PH1 1/20 0.66
▸ NOX4 Q9NPH5 1/20 0.66
▸ DUOX2 Q9NRD8 1/20 0.66
▸ DUOX1 Q9NRD9 1/20 0.66
▸ NOX1 Q9Y5S8 1/20 0.66
▸ ALDH1A1 P00352 5/20 0.50
▸ NPSR1 Q6W5P4 4/20 0.50
▸ PKM P14618 3/20 0.50
▸ TSHR P16473 3/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ GAA P10253 1/20 0.50
▸ HPGD P15428 3/20 0.49
▸ LMNA P02545 2/20 0.49
▸ RECQL P46063 1/20 0.49
▸ HTT P42858 1/20 0.48
▸ MAPT P10636 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4937076 1.00 CYBB (0.66) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL15313075 0.85 CYBB (0.69) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL4941814 0.80 KDM1A (0.66) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL16560732 0.80 CYBB (0.63) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL2027831 0.79 CYBB (1.00) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL29368383 0.79 CYBB (1.00) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL4918509 0.77 CYBB (0.57) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL4930461 0.77 CYBB (0.57) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL17210872 0.74 CYBB (0.67) CYBBNOX5NOX4DUOX2DUOX1
SCHEMBL4922738 0.72 ALDH1A1 (0.64) ALDH1A1NPSR1PKMTSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 — — EP claimed
US-20250223560-A1 NOX4 INHIBITOR COMPOSITIONS AND METHODS FOR REGENERATION OF DYSTROPHIC MUSCLE Fulcrum Therapeutics, Inc. (US) 2025-07-10 — — US claimed
EP-4205750-B1 NADPH OXIDASE INHIBITOR FOR SUPPRESSING OR IMPROVING HAIR LOSS OR TREATING ALOPECIA EADERM CO LTD (JP) 2025-04-09 — — EP claimed
US-12239655-B2 Combined modalities for nucleosides and/or NADPH oxidase (NOX) inhibitors as myeloid-specific antiviral agents EMORY UNIVERSITY (US) 2025-03-04 — — US claimed
CN-118079006-A Skin composition 国立大学法人东京医科齿科大学 2024-05-28 — — CN claimed
WO-2024006796-A2 NOX4 INHIBITOR COMPOSITIONS AND METHODS FOR REGENERATION OF DYSTROPHIC MUSCLE Fulcrum Therapeutics, Inc. (US) 2024-01-04 — — WO claimed
US-20230241029-A1 METHODS OF REDUCING POST-SURGICAL METASTASIS HELLSTRAND KRISTOFFER (SE) 2023-08-03 — — US claimed
EP-4205750-A1 COMPOSITIONS FOR SUPPRESSING OR IMPROVING HAIR LOSS AND GRAYING, AND USES THEREOF National University Corporation Tokyo Medical and Dental University (JP) 2023-07-05 — — EP claimed
US-20230047313-A1 TREATING HEART DISEASE IN MUSCULAR DYSTROPHY PATIENTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-02-16 — — US claimed
US-20220331389-A1 SKIN COMPOSITION EADERM CO., LTD. (JP) 2022-10-20 — — US claimed
US-11298372-B2 Composition for ameliorating loss of hair and graying of hair, and use thereof NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2022-04-12 — — US claimed
EP-3978020-A1 SKIN COMPOSITION National University Corporation Tokyo Medical and Dental University (JP) 2022-04-06 — — EP claimed
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 — — EP disclosed
EP-3980400-B1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS UNIV EMORY (US) 2025-08-06 — — EP disclosed
US-20250223560-A1 NOX4 INHIBITOR COMPOSITIONS AND METHODS FOR REGENERATION OF DYSTROPHIC MUSCLE Fulcrum Therapeutics, Inc. (US) 2025-07-10 — — US disclosed
US-20250114389-A1 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS UNIV EMORY (US) 2025-04-10 — — US disclosed
EP-3980400-A1 PEPTIDOMIMETICS FOR THE TREATMENT OF CORONAVIRUS AND PICORNAVIRUS INFECTIONS Emory University (US) 2022-04-13 — — EP disclosed
US-11298372-B2 Composition for ameliorating loss of hair and graying of hair, and use thereof NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2022-04-12 — — US disclosed
EP-3978020-A1 SKIN COMPOSITION National University Corporation Tokyo Medical and Dental University (JP) 2022-04-06 — — EP disclosed
CN-114026067-A Peptide mimetics for the treatment of coronavirus and picornavirus infections 埃默里大学 2022-02-08 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250223560-A1 NOX4 INHIBITOR COMPOSITIONS AND METHODS FOR REGENERATION OF DYSTROPHIC MUSCLE NOX4, NOX1, NOX3 CYBB 4/4885NOX5 6/4885NOX4 1/4885
US-20250114389-A1 NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS PNP, MTAP, NOP2 CYBB 4048/4885NOX5 2890/4885NOX4 3555/4885
US-12239655-B2 Combined modalities for nucleosides and/or NADPH oxidase (NOX) inhibitors as myeloid-specific antiviral agents NOX1, NOX3, NOX4 CYBB 6/4885NOX5 4/4885NOX4 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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