Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pamidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 19/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamidronic Acid SCHEMBL570527 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8642786 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL31388517 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL2787529 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8850008 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL5718109 | 0.95 | FDPS (0.90) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL7755905 | 0.91 | FDPS (0.82) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL18898 | 0.84 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL6270347 | 0.84 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL570526 | 0.84 | FDPS (0.78) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 56880 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146260-A1 | Transduction of gammadelta T cells with pseudotyped retroviral vectors | Miltenyi Biotec B.V. & Co. KG (DE) | 2026-05-28 | — | — | US | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122075712-A | Antitumor composition of engineering bacteria and bisphosphonate compounds for expressing hemolysin and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121755170-B | Organic phosphine modified bio-based rare earth adsorption material and preparation method and application thereof | WUHAN INSTITUTE OF TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260137678-A1 | METHODS FOR TREATING OR PREVENTING NEUROENDOCRINE TUMOR FORMATION USING XPO1 INHIBITORS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137780-A1 | MATERIALS AND METHODS FOR IMPROVED EXPANSION AND USES OF IMMUNE CELLS | JANSSEN BIOTECH INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| CN-122056884-A | Methods of treating pancreatic cancer | 坎莫森特里克斯公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260132141-A1 | PROTEIN PHOSPHATASE 2A ACTIVATORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2026-05-14 | — | — | US | claimed |
| US-12624057-B2 | Bisphosphonate quinolone conjugates and uses thereof | BIOVINC, LLC (US) | 2026-05-12 | — | — | US | claimed |
| EP-0082472-A2 | Process for the preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid | Henkel Kommanditgesellschaft auf Aktien (DE) | 1983-06-29 | — | — | EP | claimed |
| US-4378224-A | Coating for bioprosthetic device and method of making same | DOW CORNING WRIGHT CORPORATION, ARLINGTON, TENNESSEE | 1983-03-29 | — | — | US | claimed |
| EP-0027982-B1 | PROCESS FOR PREPARING 3-AMINO-1-HYDROXYPROPANE-1,1-DIPHOSPHONIC ACID | Henkel Kommanditgesellschaft auf Aktien (DE) | 1982-06-23 | — | — | EP | claimed |
| US-4327039-A | Process for the production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 1982-04-27 | — | — | US | claimed |
| EP-0027982-A1 | Process for preparing 3-amino-1-hydroxypropane-1,1-diphosphonic acid | Henkel Kommanditgesellschaft auf Aktien (DE) | 1981-05-06 | — | — | EP | claimed |
| US-4148603-A | Method of washing textiles and composition containing inorganic silicates and polycarboxylates and/or polyphosphonates | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1979-04-10 | — | — | US | claimed |
| US-4117086-A | TOOTHPASTES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1978-09-26 | — | — | US | claimed |
| US-4108962-A | PROCESS OF STABILIZATION OF ANHYDROUS DIBASIC CALCIUM PHOSPHATE AGAINST FLUORINE IONS WITH 3-AMINO-1-HYDROXYPROPANE-1,1-DIPHOSPHONIC ACID | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1978-08-22 | — | — | US | claimed |
| US-4086334-A | A CALCITONIN AND AN ADJUVANT CONTAINING CARBOXY AND/OR PHOSPHONO GROUPS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DT) | 1978-04-25 | — | — | US | claimed |
| US-3962432-A | Method of treatment of calcium disorders using aminoalkane-diophosphonic acids | HENKEL & CIE G.M.B.H. (DT) | 1976-06-08 | — | — | US | claimed |