Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Amikacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.69 |
| ▸ | RAD52 | P43351 | 1/20 | 0.69 |
| ▸ | GJB2 | P29033 | 4/20 | 0.46 |
| ▸ | GJA1 | P17302 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amikacin SCHEMBL20770189 | 0.86 | LMNA (0.52) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20516498 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15263403 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15515830 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL24437395 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL23308753 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20522644 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL20516499 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL15171896 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 | |
| Amikacin SCHEMBL2637141 | 0.84 | LMNA (1.00) | LMNAALOX15RAD52GJB2GJA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119345-A4 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GEN MILLS INC (US) | 2004-06-16 | — | — | EP | claimed |
| US-20020044968-A1 | High amount of plasticizer to facilitate plasticization of the matrix material at low shear and then reduced prior to adding the encapsulant to reduce post extrusion | GENERAL MILLS, INC. | 2002-04-18 | — | — | US | claimed |
| JP-2002511777-A | — | — | 2002-04-16 | — | — | JP | claimed |
| EP-1119345-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2001-08-01 | — | — | EP | claimed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | claimed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| US-20230218874-A1 | SWAB DELIVERY SYSTEM | ANERGENT PHARMACEUTICALS, INC. (US) | 2023-07-13 | — | — | US | disclosed |
| US-11623075-B2 | Buccal swab delivery system | ANERGENT PHARMACEUTICALS, INC. (US) | 2023-04-11 | — | — | US | disclosed |
| US-11607392-B2 | Encapsulation system for prolonged release of active agents | TREND INNOVATIONS (CA) | 2023-03-21 | — | — | US | disclosed |
| US-20200376241-A1 | BUCCAL SWAB DELIVERY SYSTEM | STATIM PHARMACEUTICALS, INC. (US) | 2020-12-03 | — | — | US | disclosed |
| US-20200297648-A1 | ENCAPSULATION SYSTEM FOR PROLONGED RELEASE OF ACTIVE AGENTS | TREND INNOVATIONS (CA) | 2020-09-24 | — | — | US | disclosed |
| US-10743604-B2 | Articles of manufacture releasing an active ingredient | NNTT TECH INC. (CA) | 2020-08-18 | — | — | US | disclosed |
| EP-1065936-A1 | ENCAPSULATION OF COMPONENTS INTO EDIBLE PRODUCTS | GENERAL MILLS, INC. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-2000021504-A1 | ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES | GENERAL MILLS, INC. (US) | 2000-04-20 | — | — | WO | disclosed |
| EP-0935523-A4 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GEN MILLS INC (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1999048372-A1 | ENCAPSULATION OF COMPONENTS INTO EDIBLE PRODUCTS | GENERAL MILLS, INC. (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0935523-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | GENERAL MILLS, INC. (US) | 1999-08-18 | — | — | EP | disclosed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | disclosed |