GNA15

Guanine nucleotide-binding protein subunit al · P30679 · GNA15 on Sugi Atlas →

14,230 patent compounds predicted against GNA15, 11,795 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Linoleic Acid (SCHEMBL7067)	1.00	1/20
SCHEMBL19452	1.00	1/20
Linoleic Acid (SCHEMBL120856)	1.00	1/20
Linoleic Acid (SCHEMBL156809)	1.00	1/20
Fasiglifam (SCHEMBL204652)	1.00	1/20
SCHEMBL214357	1.00	1/20
SCHEMBL214358	1.00	1/20
SCHEMBL258343	1.00	1/20
SCHEMBL278029	1.00	1/20
SCHEMBL278030	1.00	1/20
SCHEMBL278058	1.00	1/20
SCHEMBL278059	1.00	1/20
SCHEMBL278129	1.00	1/20
SCHEMBL278130	1.00	1/20
Dihomo-Gamma-Linolenic Acid (SCHEMBL278573)	1.00	1/20
Dihomo-Gamma-Linolenic Acid (SCHEMBL278574)	1.00	1/20
Linoleic Acid (SCHEMBL320102)	1.00	1/20
Gw9508 (SCHEMBL364468)	1.00	1/20
SCHEMBL416181	1.00	1/20
Linoleic Acid (SCHEMBL418058)	1.00	1/20

Clinical trials — most relevant to GNA15 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas	PHASE2	COMPLETED
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients	PHASE1/PHASE2	COMPLETED
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome	PHASE1/PHASE2	COMPLETED
ADH1 and ADH2 Disease Monitoring Study (DMS)	nan	ACTIVE_NOT_RECRUITING
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor.	nan	UNKNOWN
A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases	nan	COMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
An Investigation of Small Intestinal Carcinoid Carcinoma in Families	nan	UNKNOWN
Neuralized1 and RGS14 Genes	nan	COMPLETED
Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease	nan	ENROLLING_BY_INVITATION
Histamine Responsiveness in McCune-Albright Syndrome	nan	COMPLETED
Gene Analysis of Parkinson's Disease	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles	nan	ACTIVE_NOT_RECRUITING
Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer	nan	UNKNOWN
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism	nan	COMPLETED
Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes	nan	UNKNOWN
GNAO1 Natural History Study	nan	UNKNOWN
Genome Medical Sequencing for Gene Discovery	nan	RECRUITING
Germline Mutations in Pancreatic Adenocarcinoma	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GNA15 binder may also engage these)

Protein	Name	Similarity
P30678	—	1.000	P30678 →
O88302	—	1.000	O88302 →
P30677	—	0.999	P30677 →
P63095	—	0.999	P63095 →
Q8R4A8	—	0.999	Q8R4A8 →
P38409	—	0.998	P38409 →
O95837	—	0.997	O95837 →
P63092	—	0.997	P63092 →
P38406	—	0.997	P38406 →
P91907	—	0.997	P91907 →
Q93743	—	0.997	Q93743 →
P45645	—	0.997	P45645 →
Q9JID2	—	0.997	Q9JID2 →
P49084	—	0.997	P49084 →
P26981	—	0.997	P26981 →
Q28294	—	0.997	Q28294 →
P93163	—	0.996	P93163 →
P21279	—	0.996	P21279 →
P21278	—	0.996	P21278 →
P91950	—	0.996	P91950 →
GNA11	Guanine nucleotide-binding protein subunit alpha-11	0.995	landscape →
P30669	—	0.994	P30669 →
P38412	—	0.993	P38412 →
Q9TU29	—	0.993	Q9TU29 →
Q9XZV5	—	0.993	Q9XZV5 →
Q4VT31	—	0.992	Q4VT31 →
P34042	—	0.992	P34042 →
Q05337	—	0.992	Q05337 →
Q9BIG5	—	0.992	Q9BIG5 →
Q18434	—	0.992	Q18434 →