Mebhydrolin

Mebhydrolin

SCHEMBL29802

CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 2/20 1.00
ADRA1A P35348 2/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
CHRM1 P11229 1/20 1.00
DRD1 P21728 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
SLC6A3 Q01959 1/20 1.00
KCNH2 Q12809 1/20 1.00
ALDH1A1 P00352 2/20 0.97
GAA P10253 1/20 0.97
TSHR P16473 1/20 0.97
CYP1A2 P05177 2/20 0.75
CYP2D6 P10635 2/20 0.75
LMNA P02545 1/20 0.75
MAOA P21397 4/20 0.71
MAOB P27338 4/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mebhydrolin SCHEMBL29808874 1.00 ADRA2A (1.00) ADRA2AADRA1ACHRM2HTR1ACHRM1
Mebhydrolin SCHEMBL2141004 0.99 ALDH1A1 (1.00) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL8038611 0.92 CHRM2 (0.85) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL12938848 0.91 ADRA2A (0.83) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL3716403 0.91 CHRM2 (0.83) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL4130866 0.90 HRH1 (0.82) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL4125370 0.90 CHRM2 (0.81) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL19970051 0.89 CHRM2 (0.80) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL3621165 0.89 HTR6 (0.81) ADRA2AADRA1ACHRM2HTR1ACHRM1
SCHEMBL24630759 0.88 ADRA2A (0.77) ADRA2AADRA1ACHRM2HTR1ACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1363 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
EP-4658278-A1 SELECTIVE FIASMA TREATMENT Valo Health, Inc. (US) 2025-12-10 EP claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 US claimed
EP-4444277-A1 NEW INJECTABLE COMBINATION FORMULATION Nanexa AB (SE) 2024-10-16 EP claimed
WO-2024163699-A1 SELECTIVE FIASMA TREATMENT VALO HEALTH, INC. (US) 2024-08-08 WO claimed
US-20230330111-A1 ACTIVE AGENT COMBINATION FOR TREATMENT OF CANCER Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) 2023-10-19 US claimed
US-20230321008-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) 2023-10-12 US claimed
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
EP-4203944-A1 ACTIVE AGENT COMBINATION FOR TREATMENT OF CANCER Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH (DE) 2023-07-05 EP claimed
WO-2023105227-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2023-06-15 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-5807579-A Pseudoephedrine combination pharmaceutical compositions F.H. FAULDING & CO. LIMITED (AU) 1998-09-15 US claimed
EP-0794783-A4 CYCLODEXTRINS AS SUSPENDING AGENTS FOR PHARMACEUTICAL SUSPENSIONS PHARMOS CORP (US) 1998-03-04 EP claimed
EP-0794783-A1 CYCLODEXTRINS AS SUSPENDING AGENTS FOR PHARMACEUTICAL SUSPENSIONS PHARMOS CORPORATION (US) 1997-09-17 EP claimed
WO-1996016659-A1 CYCLODEXTRINS AS SUSPENDING AGENTS FOR PHARMACEUTICAL SUSPENSIONS PHARMOS CORP. (US) 1996-06-06 WO claimed
US-5332577-A DRUG DELIVERY DERMAMED (IL) 1994-07-26 US claimed
EP-0463454-A2 Transdermal administration to humans and animals DERMAMED (IL) 1992-01-02 EP claimed
US-4104382-A (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4000302-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-12-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells SMPD3, SMPD4, CMA1 ADRA2A 179/4885ADRA1A 450/4885CHRM2 100/4885
US-20230321008-A1 INHIBITORS OF ACID SPHINGOMYELINASE FOR PREVENTING AND TREATING THE COVID-19 DISEASE SMPD2, SMPD1, SMPD3 ADRA2A 253/4885ADRA1A 378/4885CHRM2 1663/4885
US-20230330111-A1 ACTIVE AGENT COMBINATION FOR TREATMENT OF CANCER GLS2, AGK, GLS ADRA2A 3436/4885ADRA1A 3160/4885CHRM2 1397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.