Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HUWE1 | Q7Z6Z7 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026869 | 0.77 | LMNA (0.48) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL5025315 | 0.77 | HUWE1 (0.49) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL5139485 | 0.75 | SLC29A1 (0.46) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL5093812 | 0.75 | SLC29A1 (0.46) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL5027000 | 0.74 | HUWE1 (0.44) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL5025268 | 0.72 | SLC29A1 (0.43) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL11046408 | 0.71 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL11026278 | 0.71 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL11049491 | 0.70 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DHTT | |
| SCHEMBL23891951 | 0.70 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHUWE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |