Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.71 |
| ▸ | METTL3 | Q86U44 | 5/20 | 0.55 |
| ▸ | ACHE | P22303 | 4/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP5 | P51878 | 1/20 | 0.52 |
| ▸ | HUWE1 | Q7Z6Z7 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029686 | 0.88 | PIK3CB (0.80) | HRH4PIK3CBMETTL3ACHENPC1 | |
| SCHEMBL14005285 | 0.84 | HRH4 (0.54) | HRH4PIK3CBMETTL3ACHECASP1 | |
| SCHEMBL14005278 | 0.83 | HRH4 (0.73) | HRH4PIK3CBMETTL3ACHEMAPK1 | |
| SCHEMBL5029684 | 0.83 | PIK3CB (1.00) | HRH4PIK3CBACHENPC1RAB9A | |
| SCHEMBL4894189 | 0.83 | HRH4 (0.53) | HRH4PIK3CBNPC1RAB9AKDM4E | |
| SCHEMBL4896683 | 0.81 | HRH4 (0.51) | HRH4PIK3CBACHECASP1CASP5 | |
| SCHEMBL4888066 | 0.80 | HTR7 (0.53) | HRH4PIK3CBMETTL3CASP1CASP5 | |
| SCHEMBL4787976 | 0.80 | HTR7 (0.53) | HRH4PIK3CBMETTL3CASP1CASP5 | |
| SCHEMBL4786499 | 0.80 | NPC1 (0.55) | ACHECASP1CASP5NPC1RAB9A | |
| SCHEMBL14005277 | 0.78 | HRH4 (0.65) | HRH4PIK3CBMETTL3ACHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| US-20080293711-A1 | Chemokine receptor modulators | METASTATIX, INC. | 2008-11-27 | — | — | US | disclosed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293711-A1 | Chemokine receptor modulators | CCR5, CCL2, CXCR4 | HRH4 1565/4885PIK3CB 1550/4885METTL3 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.