IARS2

Isoleucine--tRNA ligase, mitochondrial · Q9NSE4 · IARS2 on Sugi Atlas →

625 patent compounds predicted against IARS2, 418 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Pimasertib (SCHEMBL2021184)	1.00	1/20
Pimasertib (SCHEMBL2720659)	1.00	1/20
Pimasertib (SCHEMBL22046269)	1.00	1/20
Pimasertib (SCHEMBL29358435)	1.00	1/20
Pimasertib (SCHEMBL29604438)	1.00	1/20
Pimasertib (SCHEMBL18260054)	0.98	1/20
Pimasertib (SCHEMBL29867955)	0.98	1/20
SCHEMBL31108067	0.85	1/20
SCHEMBL2018500	0.79	1/20
SCHEMBL2018933	0.79	1/20
SCHEMBL2019046	0.79	1/20
SCHEMBL14684301	0.78	1/20
SCHEMBL22039304	0.78	1/20
SCHEMBL24634591	0.78	1/20
SCHEMBL2022966	0.74	1/20
SCHEMBL2024960	0.74	1/20
SCHEMBL2024962	0.74	1/20
SCHEMBL2020561	0.74	1/20
SCHEMBL9909420	0.73	1/20
Hydrochloric Acid (SCHEMBL2024627)	0.72	1/20

Clinical trials — most relevant to IARS2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Genomic of CONgenital Sideroblastic Anemias	nan	RECRUITING
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease	nan	COMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Natural History Study of Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL)	nan	RECRUITING
Nutritional Assessment in Mitochondrial Cytopathy	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip	nan	COMPLETED
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Mitochondrial Disease-associated ImmunoDeficiencies	nan	RECRUITING
Mitochondrial Methylation in Type 2 Diabetes	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
mtDNA Mutation Load Analysis in Mesoangioblasts	nan	RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Mitochondrial Dysfunction in Phelan-McDermid Syndrome	nan	COMPLETED
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Calf Muscle Strength in Mitochondrial Diseases	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a IARS2 binder may also engage these)

Protein	Name	Similarity
Q8BIJ6	—	1.000	Q8BIJ6 →
Q4R646	—	1.000	Q4R646 →
Q5ZKA2	—	0.999	Q5ZKA2 →
P49696	—	0.996	P49696 →
Q8VDC0	—	0.993	Q8VDC0 →
Q15031	—	0.993	Q15031 →
Q9M2T9	—	0.992	Q9M2T9 →
Q90YI3	—	0.992	Q90YI3 →
A6H7E1	—	0.992	A6H7E1 →
P28350	—	0.992	P28350 →
Q6DJ95	—	0.992	Q6DJ95 →
Q8RXK8	—	0.990	Q8RXK8 →
P11325	—	0.990	P11325 →
Q9HA77	—	0.989	Q9HA77 →
F4KE63	—	0.989	F4KE63 →
O84304	—	0.989	O84304 →
Q6GQJ7	—	0.989	Q6GQJ7 →
Q8RWT8	—	0.988	Q8RWT8 →
Q2T9L8	—	0.988	Q2T9L8 →
B0BBT3	—	0.988	B0BBT3 →
F4IPY2	—	0.988	F4IPY2 →
B0B7L8	—	0.988	B0B7L8 →
Q5RDP4	—	0.988	Q5RDP4 →
O75005	—	0.988	O75005 →
Q5JPH6	—	0.988	Q5JPH6 →
Q6PA41	—	0.987	Q6PA41 →
Q04462	—	0.987	Q04462 →
O23247	—	0.987	O23247 →
Q6MG21	—	0.987	Q6MG21 →
Q5RA20	—	0.987	Q5RA20 →