Lamifiban

Lamifiban

SCHEMBL4683

N=C(N)c1ccc(C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC(OCC(=O)O)CC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 17/20 1.00
ITGA2B P08514 17/20 1.00
F2 P00734 1/20 0.44
PLG P00747 1/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
TPSAB1 Q15661 1/20 0.44
TPSD1 Q9BZJ3 1/20 0.44
TPSG1 Q9NRR2 1/20 0.44
CYP51A1 Q16850 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lamifiban SCHEMBL871446 1.00 ITGB3 (1.00) ITGB3ITGA2BF2PLGPRSS1
SCHEMBL7282972 0.92 ITGB3 (0.86) ITGB3ITGA2BF2PRSS1
SCHEMBL7159286 0.91 ITGB3 (0.83) ITGB3ITGA2BF2PLGPRSS1
SCHEMBL7285135 0.90 ITGB3 (0.82) ITGB3ITGA2BF2PLGPRSS1
SCHEMBL7284586 0.90 ITGB3 (0.82) ITGB3ITGA2BCYP51A1CA1CA2
SCHEMBL8382276 0.90 ITGB3 (0.82) ITGB3ITGA2BCYP51A1CA1CA2
SCHEMBL7292028 0.90 ITGB3 (0.82) ITGB3ITGA2BF2PLGCYP51A1
SCHEMBL7284349 0.90 ITGB3 (0.82) ITGB3ITGA2BF2PLGCYP51A1
SCHEMBL13933091 0.90 ITGB3 (0.83) ITGB3ITGA2BF2PLGPRSS1
SCHEMBL8383672 0.89 ITGB3 (0.80) ITGB3ITGA2BCYP51A1CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2811 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
WO-2024087673-A1 ANTIPLATELET DRUG AND PREPARATION METHOD, AND ANTIPLATELET DRUG CAPTURE AGENT 中国科学院大学 2024-05-02 WO claimed
CN-115737814-A Antiplatelet medicament, preparation method thereof and antiplatelet medicament capturing agent 中国科学院大学 2023-03-07 CN claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-11136342-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2021-10-05 US claimed
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME ACORDA THERAPEUTICS, INC. 2020-05-21 US claimed
US-10377779-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2019-08-13 US claimed
CN-109893528-A Koumine treats the purposes of disorders of lipid metabolism and its related disease or illness 福建医科大学 2019-06-18 CN claimed
EP-2376074-B1 METHOD FOR IMPROVED BIOACTIVATION OF MEDICATIONS DRITTE PATENTPORTFOLIO BETEILI (DE) 2019-03-13 EP claimed
US-20180086778-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME NEUROGESX, INC. 2018-03-29 US claimed
WO-1999045913-A1 COMBINATION THERAPY AND COMPOSITION FOR ACUTE CORONARY ISCHEMIC SYNDROME AND RELATED CONDITIONS MERCK & CO., INC. (US) 1999-09-16 WO claimed
EP-0939900-A1 DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES Merck & Co., Inc. (US) 1999-09-08 EP claimed
WO-1999027962-A1 USE OF A FIBRINOGEN RECEPTOR-ANTAGONIST FOR PREVENTING DISSEMINATED INTRAVASCULAR COAGULATION WIEMANN GUNDULA (DE) 1999-06-10 WO claimed
WO-1999019463-A1 ANTICOAGULANT TEST MERCK & CO., INC. (US) 1999-04-22 WO claimed
WO-1998022821-A1 DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES MERCK & CO., INC. (US) 1998-05-28 WO claimed
WO-1998016204-A1 PROCESS FOR THE MANUFACTURE OF A PULVEROUS PREPARATION F. HOFFMANN-LA ROCHE AG (CH) 1998-04-23 WO claimed
WO-1998011896-A1 COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE MERCK & CO., INC. (US) 1998-03-26 WO claimed
WO-1997035579-A1 A METHOD FOR INHIBITING CLOT FORMATION MERCK & CO., INC. (US) 1997-10-02 WO claimed
EP-0505868-B1 N-Acyl-alpha-aminoacids derivatives HOFFMANN LA ROCHE (CH) 1995-09-13 EP claimed
EP-0505868-A2 N-Acyl-alpha-aminoacids derivatives F. HOFFMANN-LA ROCHE AG (CH) 1992-09-30 EP claimed