Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 14/20 | 1.00 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL117500 | 0.89 | MARS1 (1.00) | MARS1SMN1; SMN2TDP1POLB | |
| SCHEMBL118672 | 0.83 | MARS1 (1.00) | MARS1NPC1 | |
| SCHEMBL117716 | 0.81 | MARS1 (1.00) | MARS1 | |
| SCHEMBL27687135 | 0.80 | MARS1 (0.65) | MARS1SMN1; SMN2TDP1POLB | |
| SCHEMBL8367181 | 0.79 | MARS1 (0.65) | MARS1NPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8364783 | 0.78 | MARS1 (0.64) | MARS1NPC1SMN1; SMN2 | |
| SCHEMBL27687138 | 0.74 | SMN1; SMN2 (0.69) | MARS1SMN1; SMN2TDP1POLB | |
| SCHEMBL3436589 | 0.73 | MARS1 (0.58) | MARS1NPC1SMN1; SMN2 | |
| SCHEMBL117516 | 0.72 | SMN1; SMN2 (0.60) | MARS1SMN1; SMN2TDP1POLB | |
| SCHEMBL117498 | 0.71 | MARS1 (1.00) | MARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058133-A1 | INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF | AARS1, GARS1, TRMT1 | MARS1 55/4885SRD5A2 3080/4885NPC1 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.