Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NDUFS8 | O00217 | 3/20 | 0.57 |
| ▸ | COXFA4 | O00483 | 3/20 | 0.57 |
| ▸ | NDUFAB1 | O14561 | 3/20 | 0.57 |
| ▸ | NDUFA1 | O15239 | 3/20 | 0.57 |
| ▸ | NDUFS4 | O43181 | 3/20 | 0.57 |
| ▸ | NDUFB5 | O43674 | 3/20 | 0.57 |
| ▸ | NDUFB3 | O43676 | 3/20 | 0.57 |
| ▸ | NDUFC1 | O43677 | 3/20 | 0.57 |
| ▸ | NDUFA2 | O43678 | 3/20 | 0.57 |
| ▸ | NDUFS5 | O43920 | 3/20 | 0.57 |
| ▸ | NDUFS7 | O75251 | 3/20 | 0.57 |
| ▸ | NDUFS2 | O75306 | 3/20 | 0.57 |
| ▸ | NDUFS6 | O75380 | 3/20 | 0.57 |
| ▸ | NDUFB1 | O75438 | 3/20 | 0.57 |
| ▸ | NDUFS3 | O75489 | 3/20 | 0.57 |
| ▸ | NDUFB6 | O95139 | 3/20 | 0.57 |
| ▸ | NDUFA3 | O95167 | 3/20 | 0.57 |
| ▸ | NDUFB4 | O95168 | 3/20 | 0.57 |
| ▸ | NDUFB8 | O95169 | 3/20 | 0.57 |
| ▸ | NDUFB2 | O95178 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12081709 | 1.00 | NDUFS8 (0.57) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL28529405 | 1.00 | NDUFS8 (0.57) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL28061786 | 0.94 | NDUFS8 (0.58) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL13575106 | 0.91 | CA12 (0.54) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL21043916 | 0.89 | CA12 (0.64) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL1095981 | 0.87 | CA12 (0.63) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL19831442 | 0.87 | CA12 (0.63) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL4293165 | 0.87 | CA12 (0.63) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 | |
| SCHEMBL3469861 | 0.87 | CA12 (0.66) | CA12CA9CA1CA6CA7 | |
| SCHEMBL3470086 | 0.86 | NDUFS8 (0.53) | NDUFS8COXFA4NDUFAB1NDUFA1NDUFS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | UNIVERSITY OF DELAWARE (US) | 2023-09-26 | — | — | US | disclosed |
| US-20220106278-A1 | REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS | UNIVERSITY OF DELAWARE (US) | 2022-04-07 | — | — | US | disclosed |
| US-9168242-B2 | Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia | UNIGEN, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140088183-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | UNIGEN, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-8568799-B2 | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia | UNIGEN, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120329863-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | UNIGEN, INC. (US) | 2012-12-27 | — | — | US | disclosed |
| US-8263558-B2 | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins | ABBOTT LABORATORIES (US) | 2012-09-11 | — | — | US | disclosed |
| US-8124134-B2 | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia | UNIGEN, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090311723-A1 | FLUORESCENCE-BASED ASSAY FOR MONOACYLGLYCEROL LIPASE COMPATIBLE WITH INHIBITOR SCREENING | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090311723-A1 | FLUORESCENCE-BASED ASSAY FOR MONOACYLGLYCEROL LIPASE COMPATIBLE WITH INHIBITOR SCREENING | WYETH (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090214515-A1 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2009-08-27 | — | — | US | disclosed |
| EP-1963363-A2 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | Abbott Laboratories (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007064917-A2 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS | ABBOTT LABORATORIES (US) | 2007-06-07 | — | — | WO | disclosed |
| US-20060269627-A1 | Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia | UNIGEN PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7108868-B2 | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia | UNIGEN PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1490081-A4 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | UNIGEN PHARMACEUTICALS INC (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1490081-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | Unigen Pharmaceuticals, Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082312-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | UNIGEN PHARMACEUTICALS, INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030180402-A1 | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia | UNIGEN PHARMACEUTICALS, INC. | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088183-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | ALOX5, ALOX15, ALOX15B | NDUFS8 509/4885COXFA4 123/4885NDUFAB1 602/4885 |
| US-20090311723-A1 | FLUORESCENCE-BASED ASSAY FOR MONOACYLGLYCEROL LIPASE COMPATIBLE WITH INHIBITOR SCREENING | MGLL, LIPC, LIPA | NDUFS8 4473/4885COXFA4 1306/4885NDUFAB1 1629/4885 |
| US-11767302-B2 | Reagents and methods for tetrazine synthesis | TST, CYP4F8, CYP4Z1 | NDUFS8 289/4885COXFA4 1035/4885NDUFAB1 1393/4885 |
| US-20220106278-A1 | REAGENTS AND METHODS FOR TETRAZINE SYNTHESIS | TST, CYP4F8, CYP4Z1 | NDUFS8 289/4885COXFA4 1035/4885NDUFAB1 1393/4885 |
| US-20030180402-A1 | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia | ALOX5, ALOX5AP, ALOX15 | NDUFS8 813/4885COXFA4 119/4885NDUFAB1 601/4885 |
| US-20120329863-A1 | ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA | ALOX5, ALOX15, ALOX15B | NDUFS8 509/4885COXFA4 123/4885NDUFAB1 602/4885 |
| US-20060269627-A1 | Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia | ALOX5, ALOX5AP, ALOX15 | NDUFS8 813/4885COXFA4 119/4885NDUFAB1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.