Sugi Predict

Sugi Predict / Targets / MT-ND6

MT-ND6

NADH-ubiquinone oxidoreductase chain 6 · P03923 · MT-ND6 on Sugi Atlas →

2,598 patent compounds predicted against MT-ND6, 1,476 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL8491443 SCHEMBL8491443 0.56 4/20
SCHEMBL8489900 SCHEMBL8489900 0.52 4/20
SCHEMBL8489907 SCHEMBL8489907 0.52 4/20
SCHEMBL8492838 SCHEMBL8492838 0.52 4/20
SCHEMBL8492845 SCHEMBL8492845 0.52 4/20
SCHEMBL8489902 SCHEMBL8489902 0.51 4/20
SCHEMBL8489908 SCHEMBL8489908 0.51 4/20
SCHEMBL8491154 SCHEMBL8491154 0.51 4/20
SCHEMBL8491160 SCHEMBL8491160 0.51 4/20
SCHEMBL8491619 SCHEMBL8491619 0.50 4/20
SCHEMBL8491624 SCHEMBL8491624 0.50 4/20
SCHEMBL8491634 SCHEMBL8491634 0.50 4/20
SCHEMBL8494171 SCHEMBL8494171 0.50 4/20
SCHEMBL8494175 SCHEMBL8494175 0.50 4/20
SCHEMBL8494177 SCHEMBL8494177 0.50 4/20
7-Prenyloxycoumarin 7-Prenyloxycoumarin (SCHEMBL4898255) 0.79 3/20
SCHEMBL712741 SCHEMBL712741 0.57 3/20
Geiparvarin Geiparvarin (SCHEMBL2532495) 0.56 3/20

Clinical trials — most relevant to MT-ND6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease PHASE3COMPLETED
A Single Intravitreal Injection of rAAV2-ND4 for the Treatment of Leber's Hereditary Optic Neuropathy PHASE2/PHASE3UNKNOWN
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease PHASE2RECRUITING
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder PHASE2COMPLETED
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) PHASE1/PHASE2NOT_YET_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Diagnostic Odyssey Survey 2 nanCOMPLETED
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Red Light Ptosis Proof-of-Concept nanUNKNOWN
mtDNA Mutation Load Analysis in Mesoangioblasts nanRECRUITING
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months nanUNKNOWN
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
An Observational Study of Patients With Primary Mitochondrial Disease (SPIMM-300) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MT-ND6 binder may also engage these)

ProteinNameSimilarity
Q9T9X3 — 0.998 Q9T9X3 →
P92700 — 0.997 P92700 →
Q34573 — 0.997 Q34573 →
Q9T9V6 — 0.997 Q9T9V6 →
Q95710 — 0.996 Q95710 →
Q9T9W5 — 0.996 Q9T9W5 →
O21336 — 0.996 O21336 →
Q9ZZY0 — 0.991 Q9ZZY0 →
P48657 — 0.991 P48657 →
O03206 — 0.990 O03206 →
Q9ZXX5 — 0.990 Q9ZXX5 →
P24980 — 0.990 P24980 →
Q9G6M4 — 0.990 Q9G6M4 →
P92486 — 0.988 P92486 →
Q9TA18 — 0.987 Q9TA18 →
Q94VK5 — 0.987 Q94VK5 →
O79438 — 0.986 O79438 →
Q9G3S5 — 0.986 Q9G3S5 →
Q8LX23 — 0.985 Q8LX23 →
Q8W9M5 — 0.985 Q8W9M5 →
Q96070 — 0.985 Q96070 →
Q38PR1 — 0.985 Q38PR1 →
Q2I3G3 — 0.983 Q2I3G3 →
Q953I3 — 0.983 Q953I3 →
Q36460 — 0.982 Q36460 →
Q8W9G2 — 0.982 Q8W9G2 →
P03925 — 0.981 P03925 →
P03924 — 0.979 P03924 →
Q71PB7 — 0.979 Q71PB7 →
P41300 — 0.977 P41300 →